芴甲氧羰基-L-谷氨酸 1-叔丁酯合成路线 （共 8 条）
反应条件
sodium carbonate in 1,4-dioxane T=24°C; 20 h;
参考文献
Abraham; Nair; Kisliuk; Gaumont; Galivan
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 711 - 717
反应条件
hydrogen; palladium on activated charcoal
参考文献
Journal of the Chemical Society. Perkin Transactions 1, , # 8 p. 1042 - 1049
反应条件
1: POCl3; pyridine 2: H2 / Pd/C View Scheme
参考文献
Journal of the Chemical Society. Perkin Transactions 1, , # 8 p. 1042 - 1049
反应条件
sodium carbonate; toluene-4-sulfonic acid 1) dioxane, gas pressure: 350 mbar, 3 d, r.t., 2) dioxane, 0 deg C to r.t., 14 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Synthesis, , # 7 p. 571 - 572
反应条件
piperidine in N,N-dimethyl-formamide 0.333333 h;
参考文献
Gengrinovitch, Stela; Izakovich, Esther
Patent: US2007/72800 A1, 2007 ;
Location in patent: Page/Page column 13 ;
反应条件
dicyclohexyl-carbodiimide in dichloromethane T=20°C; 3 h;
参考文献
Feng, Fei; Miura, Nobuaki; Isoda, Norikazu; Sakoda, Yoshihiro; Okamatsu, Masatoshi; Kida, Hiroshi; Nishimura, Shin-Ichiro
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 12 p. 3772 - 3776
参考文献
Tomsho, John W.; McGuire, John J.; Coward, James K.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 18 p. 3388 - 3398
反应条件
1: dicyclohexylcarbodiimide / CH2Cl2 / 0.25 h
2: KH poliamide resin, 4-(dimethylamino)pyridine, N-methylmorpholine, piperidine, 1percent TFA
3: 0.1 N HCl / tetrahydrofuran / 18 h / 25 °C
View Scheme
参考文献
Abraham; Nair; Kisliuk; Gaumont; Galivan
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 711 - 717
