6-甲氧基-8-硝基喹啉合成路线 （共 32 条）
反应条件
1: 100 percent / H2 / Raney-Ni / 1 h / 20 °C / 2585.74 Torr
2: Et3N / 6 h / 150 °C
View Scheme
参考文献
Armer, Richard E.; Barlow, Jacqueline S.; Chopra, Narinder; Dutton, Christopher J.; Greenway, David H.J.; Greenwood, Sean D.W.; Lad, Nita; Shaw, Jonothan; Thompson, Adrian P.; Thong, Kam-Wah; Tommasini, Ivan
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 16 p. 2425 - 2430
反应条件
1: 100 percent / H2 / Raney-Ni / 1 h / 20 °C / 2585.74 Torr
2: Et3N / 6 h / 150 °C
View Scheme
参考文献
Armer, Richard E.; Barlow, Jacqueline S.; Chopra, Narinder; Dutton, Christopher J.; Greenway, David H.J.; Greenwood, Sean D.W.; Lad, Nita; Shaw, Jonothan; Thompson, Adrian P.; Thong, Kam-Wah; Tommasini, Ivan
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 16 p. 2425 - 2430
反应条件
(NH4)2S2O8; sulfuric acid; silver nitrate in acetonitrile
0.166667 h;
参考文献
Jain, Rahul; Jain, Meenakshi; Singh, Prati Pal; Singh, Sacita; Sachdeva, Sandeep; Misra, Vijai; Ramarao, Poduri; Kaul, Chaman Lal; Tikoo, Kulbhushan
Patent: US2004/192724 A1, 2004 ;
Location in patent: Page 10 ;
反应条件
1: AgNO3; ammonium persulfate; H2SO4 / acetonitrile / 0.25 h / 70 - 80 °C
2: H2; Raney Ni / ethanol / 0.75 h / 2327.17 Torr
View Scheme
参考文献
Jain, Meenakshi; Vangapandu, Suryanarayana; Sachdeva, Sandeep; Singh, Savita; Singh, Prati P.; Jena, Gopa B.; Tikoo, Kulbhushan; Ramarao, Poduri; Kaul, Chaman L.; Jain, Rahul
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 285 - 287
反应条件
1: 100 percent / H2 / Raney-Ni / 1 h / 20 °C / 2585.74 Torr
2: 22 percent / Et3N / 6 h / 150 °C
View Scheme
参考文献
Armer, Richard E.; Barlow, Jacqueline S.; Chopra, Narinder; Dutton, Christopher J.; Greenway, David H.J.; Greenwood, Sean D.W.; Lad, Nita; Shaw, Jonothan; Thompson, Adrian P.; Thong, Kam-Wah; Tommasini, Ivan
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 16 p. 2425 - 2430
反应条件
(NH4)2S2O8; sulfuric acid; silver nitrate in water; acetonitrile
T=70°C; 0.166667 h;
参考文献
Jain, Meenakshi; Vangapandu, Suryanarayana; Sachdeva, Sandeep; Jain, Rahul
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 5 p. 1003 - 1010
反应条件
1: 12 percent / AgNO3; aq. H2SO4; (NH4)2S2O8 / acetonitrile; H2O / 0.17 h / 70 °C
2: 88 percent / H2 / Raney Ni / ethanol / 0.75 h / 2327.17 Torr
View Scheme
参考文献
Jain, Meenakshi; Vangapandu, Suryanarayana; Sachdeva, Sandeep; Jain, Rahul
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 5 p. 1003 - 1010
反应条件
1: 100 percent / H2 / Raney-Ni / 1 h / 20 °C / 2585.74 Torr
2: 65 percent / NEt3 / acetonitrile / Heating
3: 83 percent / LiAlH4 / tetrahydrofuran
4: NaCNBH3 / 24 h / 20 °C
View Scheme
参考文献
Armer, Richard E.; Barlow, Jacqueline S.; Chopra, Narinder; Dutton, Christopher J.; Greenway, David H.J.; Greenwood, Sean D.W.; Lad, Nita; Shaw, Jonothan; Thompson, Adrian P.; Thong, Kam-Wah; Tommasini, Ivan
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 16 p. 2425 - 2430
反应条件
1: iron; calcium carbonate; chloroform; bromine / Reagens 4:Wasser, Erwaermen des Reaktionsprodukts mit einem Gemisch von Cyclohexen und Benzol
2: 130 - 140 °C / unter Druck
3: Na2S2; H2O
View Scheme
参考文献
Elderfield et al.
Journal of the American Chemical Society, vol. 77, p. 4819
反应条件
1: 100 percent / H2 / Raney-Ni / 1 h / 20 °C / 2585.74 Torr
2: Et3N / 6 h / 150 °C
3: H2NNH2*H2O / ethanol / 3 h / Heating
View Scheme
参考文献
Armer, Richard E.; Barlow, Jacqueline S.; Chopra, Narinder; Dutton, Christopher J.; Greenway, David H.J.; Greenwood, Sean D.W.; Lad, Nita; Shaw, Jonothan; Thompson, Adrian P.; Thong, Kam-Wah; Tommasini, Ivan
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 16 p. 2425 - 2430
