2-(4-氟苯基)-1-环己醇合成路线 (共 4 条)
反应条件
1: 1-bromo-4-fluorobenzene With n-butyllithium in diethyl ether
T=-78°C; 0.0833333 h;
2: cyclohexane-1,2-epoxide With boron trifluoride diethyl etherate in diethyl ether
T=-78 - -50°C; 4 h;
3: With ammonium chloride in diethyl ether; water
参考文献
Ceccarelli, Simona Maria; Jolidon, Synese; Pinard, Emmanuel; Thomas, Andrew William
Patent: US2005/154001 A1, 2005 ;
Location in patent: Page/Page column 8 ;
反应条件
copper(I) bromide dimethylsulfide complex in tetrahydrofuran
T=0°C;
参考文献
Pinard, Emmanuel; Ceccarelli, Simona M.; Stalder, Henri; Alberati, Daniela
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 349 - 353
参考文献
Pfizer Inc.
Patent: US4143139 A1, 1979 ;
反应条件
sulfur trioxide pyridine complex; triethylamine in dimethyl sulfoxide
T=0°C; 1.25 h; Product distribution / selectivity;
参考文献
Ceccarelli, Simona Maria; Jolidon, Synese; Pinard, Emmanuel; Thomas, Andrew William
Patent: US2005/154001 A1, 2005 ;
Location in patent: Page/Page column 8 ;