2-溴-4-氟-5-氯苯胺合成路线 （共 3 条）
反应条件
pyridine; bromine in dichloromethane T=0°C; 1 h;
参考文献
Adams, David R.; Duncton, Matthew A.J.; Roffey, Jonathan R.A.; Spencer, John
Tetrahedron Letters, 2002 , vol. 43, # 42 p. 7581 - 7583
反应条件
1.1: triphenylphosphine; palladium(II) acetate / tetrahydrofuran / 0.08 h / 20 °C 1.2: 62 percent / tetrahydrofuran / 1 h / Heating 2.1: 53 percent / lithium chloride; palladium(II) chloride; p-benzoquinone / tetrahydrofuran / 16 h / Heating View Scheme
参考文献
Adams, David R.; Duncton, Matthew A.J.; Roffey, Jonathan R.A.; Spencer, John
Tetrahedron Letters, 2002 , vol. 43, # 42 p. 7581 - 7583
反应条件
1: 2-bromo-5-chloro-4-fluoroaniline With palladium diacetate; triphenylphosphine in tetrahydrofuran
T=20°C; 0.0833333 h;
2: vinyl-magnesium bromide in tetrahydrofuran
Grignard reaction; 1 h; Heating;
参考文献
Adams, David R.; Duncton, Matthew A.J.; Roffey, Jonathan R.A.; Spencer, John
Tetrahedron Letters, 2002 , vol. 43, # 42 p. 7581 - 7583
