4-氨基-N-(1-苯基乙基)苯甲酰胺合成路线 （共 4 条）
反应条件
1: With SnCl2·2H2O in ethyl acetate
2 h; Reflux;
2: With sodium hydrogencarbonate in water; ethyl acetate
pH=7 - 8;
参考文献
Bissinger, Elisabeth-Maria; Heinke, Ralf; Spannhoff, Astrid; Eberlin, Adrien; Metzger, Eric; Cura, Vincent; Hassenboehler, Pierre; Cavarelli, Jean; Schuele, Roland; Bedford, Mark T.; Sippl, Wolfgang; Jung, Manfred
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 12 p. 3717 - 3731
反应条件
1: 70 percent / 20percent (w/v) K2CO3 / tetrahydrofuran / 12 h / Heating
2: 80 percent / H2 / 5percent Pd/C / ethanol / 3 h / 2327.2 Torr
View Scheme
参考文献
Clark; Wells; Sansom; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 6 p. 779 - 782
反应条件
1: 70 percent / 20percent (w/v) K2CO3 / tetrahydrofuran / 12 h / Heating
2: 80 percent / H2 / 5percent Pd/C / ethanol / 3 h / 2327.2 Torr
View Scheme
参考文献
Clark; Wells; Sansom; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 6 p. 779 - 782
反应条件
1.1: 4-methyl-morpholine / dichloromethane / 0 - 20 °C
2.1: SnCl2·2H2O / ethyl acetate / 2 h / Reflux
2.2: pH 7 - 8
View Scheme
参考文献
Bissinger, Elisabeth-Maria; Heinke, Ralf; Spannhoff, Astrid; Eberlin, Adrien; Metzger, Eric; Cura, Vincent; Hassenboehler, Pierre; Cavarelli, Jean; Schuele, Roland; Bedford, Mark T.; Sippl, Wolfgang; Jung, Manfred
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 12 p. 3717 - 3731
