乙基[3,5-二碘-4-(4-甲氧基苯氧基)苯基]乙酸酯合成路线 （共 7 条）
反应条件
1: aqueous HI; red phosphorus; acetic acid 2: aqueous methanol. NH3 / anschliessendes Behandeln mit wss. Jod-KI-Loesung View Scheme
参考文献
Wilkinson
Biochemical Journal, 1956 , vol. 63, p. 601,603
反应条件
1: aqueous HI; red phosphorus; acetic acid 2: methanol; aqueous NH3 / anschliessendes Behandeln mit Jod in Methanol View Scheme
参考文献
VASCULAR VISION PHARMACEUTICAL COMPANY
Patent: US2011/105482 A1, 2011 ;
反应条件
phosphorus; hydrogen iodide; acetic acid 1 h; Reflux;
参考文献
Bridoux, Alexandre; Khan, Riaz A.; Chen, Celei; Cheve, Gwenael; Cui, Huadong; Dyskin, Evgeny; Yasri, Aziz; Mousa, Shaker A.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2011 , vol. 26, # 6 p. 871 - 882
反应条件
1: With sulfuric acid; acetic acid; sodium nitrite
T=0°C; 1.75 h;
2: With iodine; urea; sodium iodide in chloroform; water
T=20°C; 1 h;
参考文献
Bridoux, Alexandre; Khan, Riaz A.; Chen, Celei; Cheve, Gwenael; Cui, Huadong; Dyskin, Evgeny; Yasri, Aziz; Mousa, Shaker A.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2011 , vol. 26, # 6 p. 871 - 882
反应条件
1.1: pyridine; p-toluenesulfonyl chloride / 0.5 h / 95 - 100 °C
1.2: 2 h / 125 °C / Inert atmosphere
2.1: hydrogen / Lindlar catalyst / ethanol
3.1: sodium nitrite; sulfuric acid; acetic acid / 1.75 h / 0 °C
3.2: 1 h / 20 °C
View Scheme
参考文献
VASCULAR VISION PHARMACEUTICAL COMPANY
Patent: US2011/105482 A1, 2011 ;
反应条件
1.1: hydrogen / Lindlar catalyst / ethanol
2.1: sodium nitrite; sulfuric acid; acetic acid / 1.75 h / 0 °C
2.2: 1 h / 20 °C
View Scheme
参考文献
VASCULAR VISION PHARMACEUTICAL COMPANY
Patent: US2011/105482 A1, 2011 ;
反应条件
1.1: pyridine; p-toluenesulfonyl chloride / 0.5 h / 95 - 100 °C
1.2: 2 h / 125 °C / Inert atmosphere
2.1: hydrogen / Lindlar catalyst / ethanol
3.1: sodium nitrite; sulfuric acid; acetic acid / 1.75 h / 0 °C
3.2: 1 h / 20 °C
View Scheme
参考文献
VASCULAR VISION PHARMACEUTICAL COMPANY
Patent: US2011/105482 A1, 2011 ;
