6,9-二氯-2-甲氧基吖啶合成路线 （共 38 条）
反应条件
in N,N-dimethyl-formamide
T=100°C; 2 h;
参考文献
Balbi; Sottofattori; Grandi; Mazzei; Pyshnyi, Dmitri S.; Lokhov, Sergej G.; Lebedev, Alexander V.
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 10 p. 1903 - 1910
反应条件
1: 71 percent / 4-methylmorpholine; phenol / 2 h / 100 °C
2: 100 percent / trifluoroacetic acid / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Boulanger, Caroline; Di Giorgio, Christophe; Vierling, Pierre
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 12 p. 1295 - 1306
参考文献
Holliman; Mann
Journal of the Chemical Society, 1945 , p. 45,47
反应条件
potassium carbonate in N,N-dimethyl-formamide
Arylation; Heating;
参考文献
Girault, Sophie; Grellier, Philippe; Berecibar, Amaya; Maes, Louis; Mouray, Elisabeth; Lemiere, Pascal; Debreu, Marie-Ange; Davioud-Charvet, Elisabeth; Sergheraert, Christian
Journal of Medicinal Chemistry, 2000 , vol. 43, # 14 p. 2646 - 2654
反应条件
phenol
T=120°C; 2 h;
参考文献
Gallo, Sandrine; Atifi, Siham; Mahamoud, Abdallah; Santelli-Rouvier, Christiane; Wolfart, Krisztina; Molnar, Jozsef; Barbe, Jacques
European Journal of Medicinal Chemistry, 2003 , vol. 38, # 1 p. 19 - 26
参考文献
Kitani
Nippon Kagaku Zasshi, 1954 , vol. 75, p. 475,476
Chem.Abstr., 1955 , p. 10297
参考文献
Parke,Davis and Co.
Patent: US2880210 , 1956 ;
Full Text Show Details
Puschkarewa; Warjuchina
Doklady Akademii Nauk SSSR, 1955 , vol. 103, p. 257
Chem.Abstr., 1956 , p. 5667
反应条件
hydrazine hydrate
T=20 - 150°C; 0.0833333 h; microwave irradiation in sealed tube;
参考文献
Gemma, Sandra; Kukreja, Gagan; Tripaldi, Pierangela; Altarelli, Maria; Bernetti, Matteo; Franceschini, Silvia; Savini, Luisa; Campiani, Giuseppe; Fattorusso, Caterina; Butini, Stefania
Tetrahedron Letters, 2008 , vol. 49, # 13 p. 2074 - 2077
反应条件
1: 84 percent / thiourea / dioxane
2: 4.5 M NaOH / dimethylformamide
3: dimethylformamide
View Scheme
参考文献
Gaydukevich, A. N.; Kazakov, G. P.; Kravchenko, A. A.; Porokhnyak, L. A.; Pinchuk, V. V.; Velikii, D. L.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 9 p. 633 - 636
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 9 p. 1067 - 1070
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=118°C; 6 h;
参考文献
Wang, Shan-Shue; Lee, Yi-Jen; Hsu, Shih-Chung; Chang, Hsueh-O; Yin, Wei-Kung; Chang, Lien-Shange; Chou, Shan-Yen
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 735 - 748
