3,4,5-三甲氧基苯甲醛合成路线 （共 427 条）
反应条件
N-ethyl-N,N-diisopropylamine
1.) ether, 0 deg C, 2.) CH2Cl2, reflux; Yield given. Multistep reaction;
参考文献
Marino, J. P.; Jaen, Juan C.
Synthetic Communications, 1983 , vol. 13, # 13 p. 1057 - 1066
反应条件
1: ethanol / Heating
2: 60 percent / acetonitrile / 3 h / electrolysis (HClO4, Et4NClO4)
View Scheme
参考文献
Crljenak, Senka; Tabakovic, Ibro; Jeremic, Dragoslav; Gaon, Igor
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1983 , vol. 37, # 6 p. 527 - 536
反应条件
1: ethanol / Heating
2: 83 percent / acetonitrile / 3 h / electrolysis (HClO4, Et4NClO4)
View Scheme
参考文献
Crljenak, Senka; Tabakovic, Ibro; Jeremic, Dragoslav; Gaon, Igor
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1983 , vol. 37, # 6 p. 527 - 536
反应条件
1: 79 percent / n-Bu2NH / diethyl ether / 3 h / 20 °C
2: TsOH / benzene / 0.5 h / 50 °C
3: NaH / ethanol / 18 h / 20 °C
4: aq. HCl / methanol / 1 h / 20 °C
5: H2 / Pd/C / 2 h / 20 °C
View Scheme
参考文献
Latey, P. P.; Deshpande, V. H.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 299 - 300
反应条件
1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / 0 °C
1.2: tetrahydrofuran; hexane / 16 h / -78 - 20 °C
2.1: Na / tetrahydrofuran / 7 h / 20 °C
2.2: 78 percent / H2O / tetrahydrofuran / 0 °C
View Scheme
参考文献
Azzena, Ugo; Dettori, Giovanna; Idini, Maria Vittoria; Pisano, Luisa; Sechi, Grazia
Tetrahedron, 2003 , vol. 59, # 40 p. 7961 - 7966
反应条件
acetic acid
Heating;
参考文献
Salman, Mohammad; Ray, Suprabhat
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 6 p. 477 - 479
反应条件
1: 1.) BuLi, 3.) MnO2
2: 90.8 percent / 2 N aq HBr / dioxane / 2.5 h / 50 °C
View Scheme
参考文献
Obrecht, Daniel; Weiss, Bettina
Helvetica Chimica Acta, 1989 , vol. 72, p. 117 - 122
反应条件
1.1: bromine / methanol / 20 °C
2.1: nBuLi / hexane; tetrahydrofuran / 20 °C
2.2: hexane; tetrahydrofuran / 3 h / 20 °C
View Scheme
参考文献
Appukkuttan, Prasad; Dehaen, Wim; Van Der Eycken, Erik
Organic Letters, 2005 , vol. 7, # 13 p. 2723 - 2726
反应条件
1: 84 percent / butyllithium / tetrahydrofuran / Ambient temperature
2: pyridine
3: N-chlorosuccinimide, aqueous aceton / 10 - 16 °C
View Scheme
参考文献
Matsumoto, Takashi; Imai, Sachihiko; Usui, Shuji; Suetsugu, Akira; Kawatsu, Shunzi; Yamaguchi, Tadashi
Chemistry Letters, 1984 , p. 67 - 70
反应条件
1: pyridine; piperidine
2: thionyl chloride; N,N-dimethylformamide / 1,2-dichloro-ethane / 6 h / Heating
View Scheme
参考文献
Dimmock, Jonathan R.; Jha, Amitabh; Zello, Gordon A.; Quail, J. Wilson; Oloo, Eliud O.; Nienaber, Kurt H.; Kowalczyk, Earl S.; Allen, Theresa M.; Santos, Cheryl L.; De Clercq, Erik; Balzarini, Jan; Manavathu, Elias K.; Stables, James P.
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 12 p. 961 - 972
