3-哌啶-1-基-丙胺酸甲酯合成路线 （共 7 条）
反应条件
1: With triethylamine in dichloromethane 2: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 3: With sodium hydroxide; water in tetrahydrofuran T=0°C;
参考文献
WO2007/138033 A1, ;
Page/Page column 31 ;
反应条件
lithium aluminium tetrahydride in diethyl ether 10 h; Heating;
参考文献
Arendaruk, A. P.; Abramova, N. A.; Skoldinov, A. P.; Kharkevich, D. A.
Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 7 p. 464 - 467
Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 7 p. 802 - 806
反应条件
1: KI / acetone / 12 h / Heating 2: SOCl2 / tetrahydrofuran / 2 h / 50 °C 3: KOH; KI / H2O / 12 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 5 p. 1128 - 1141
反应条件
1: SOCl2 / tetrahydrofuran / 2 h / 50 °C 2: KOH; KI / H2O / 12 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 5 p. 1128 - 1141
反应条件
potassium hydroxide; potassium iodide in water 12 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 5 p. 1128 - 1141
反应条件
1: 62 percent / diethyl ether / 12 h / Heating 2: 72 percent / LiAlH4 / diethyl ether / 10 h / Heating View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 20, # 7 p. 464 - 467
Khimiko-Farmatsevticheskii Zhurnal, , vol. 20, # 7 p. 802 - 806
参考文献
Journal of the American Chemical Society, , vol. 72, p. 2661,2664, 2665
