氨基-(3,4,5-三甲氧基-苯基)-乙酸合成路线 （共 8 条）
反应条件
1: Na2S2O5 / methanol; H2O / 2 h / 35 °C
2: 84 percent / aq. H2O2; K2CO3 / dimethylsulfoxide / 16.5 h / 21 - 35 °C
3: 92 percent / NaOH; H2O / various solvent(s) / 3.5 h / Heating
4: hydrazine hydrate; NaOH / Pd/C / H2O; various solvent(s) / 10 h / Heating
View Scheme
参考文献
Davies, Antony J.; Ashwood, Michael S.; Cottrell, Ian F.
Synthetic Communications, 2000 , vol. 30, # 6 p. 1095 - 1102
反应条件
sodium hydroxide; hydrazine hydrate; palladium on activated charcoal in water
Hydrogenolysis; 10 h; Heating;
参考文献
Davies, Antony J.; Ashwood, Michael S.; Cottrell, Ian F.
Synthetic Communications, 2000 , vol. 30, # 6 p. 1095 - 1102
反应条件
1: 84 percent / aq. H2O2; K2CO3 / dimethylsulfoxide / 16.5 h / 21 - 35 °C
2: 92 percent / NaOH; H2O / various solvent(s) / 3.5 h / Heating
3: hydrazine hydrate; NaOH / Pd/C / H2O; various solvent(s) / 10 h / Heating
View Scheme
参考文献
Davies, Antony J.; Ashwood, Michael S.; Cottrell, Ian F.
Synthetic Communications, 2000 , vol. 30, # 6 p. 1095 - 1102
反应条件
1: 92 percent / NaOH; H2O / various solvent(s) / 3.5 h / Heating
2: hydrazine hydrate; NaOH / Pd/C / H2O; various solvent(s) / 10 h / Heating
View Scheme
参考文献
Davies, Antony J.; Ashwood, Michael S.; Cottrell, Ian F.
Synthetic Communications, 2000 , vol. 30, # 6 p. 1095 - 1102
反应条件
1: 1.) LAH, 2.) PDC / 1.) THF, 2.) CH2Cl2
2: NH3 / methanol / 5 h / 45 °C
3: 1.) HCl gas, 2.) SOCl2 / 1.) room temperature, 12 h, 2.) 55 deg C, 3 h
4: Et3N / CH2Cl2 / 2 h / Ambient temperature
5: 6N HCl / Heating
View Scheme
参考文献
Bois-Choussy; Zhu
Journal of Organic Chemistry, 1998 , vol. 63, # 16 p. 5662 - 5665
反应条件
1: 1.) HCl gas, 2.) SOCl2 / 1.) room temperature, 12 h, 2.) 55 deg C, 3 h
2: Et3N / CH2Cl2 / 2 h / Ambient temperature
3: 6N HCl / Heating
View Scheme
参考文献
Bois-Choussy; Zhu
Journal of Organic Chemistry, 1998 , vol. 63, # 16 p. 5662 - 5665
反应条件
hydrogenchloride
Heating;
参考文献
Bois-Choussy; Zhu
Journal of Organic Chemistry, 1998 , vol. 63, # 16 p. 5662 - 5665
参考文献
Schmidt; Rosenkranz
Justus Liebigs Annalen der Chemie, 1976 , vol. no.1, p. 129 - 139
