(5-氟-2-氧代-1,2-二氢嘧啶-4-基)氨基甲酸戊酯合成路线 （共 2 条）
反应条件
1: in acetonitrile Inert atmosphere; 2: With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane in acetonitrile T=20°C; 0.5 h; 3: With trimethylsilyl trifluoromethanesulfonate in acetonitrile T=-78 - 20°C;
参考文献
Coll Farma S.L.
Patent: EP2241556 A1, 2010 ;
Location in patent: Page/Page column 9 ;
反应条件
1: acetonitrile / 0.5 h / 75 °C 2: 2,6-di-tert-butyl-4-methylpyridinium triflate / acetonitrile / 140 °C 3: water; sodium hydroxide / methanol / 0.03 h / 20 °C View Scheme
参考文献
Shen, Bo; Jamison, Timothy F.
Organic Letters, 2012 , vol. 14, # 13 p. 3348 - 3351
