1-[(4-氟苯基)甲基]-2,5-吡咯烷二酮合成路线 （共 4 条）
反应条件
1: pyrrolidin-1-yl-2,5-dione With potassium carbonate in acetone
0.0833333 h;
2: 4-bromomethyl-fluorobenzene in acetone
Heating / reflux;
参考文献
GILEAD SCIENCES, LLC
Patent: US2008/39487 A1, 2008 ;
Location in patent: Page/Page column 16-17 ;
反应条件
4-(N,N-dimethlyamino)pyridine; acetic acid
24 h; Heating;
参考文献
Verschueren, Wim G.; Dierynck, Inge; Amssoms, Katie I. E.; Hu, Lili; Boonants, Paul M. J. G.; Pille, Geert M. E.; Daeyaert, Frits F. D.; Hertogs, Kurt; Surleraux, Dominique L. N. G.; Wigerinck, Piet B. T. P.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 1930 - 1940
反应条件
1: in chloroform
T=20°C; 3 h;
2: With sodium acetate; acetic anhydride
T=138°C; 3 h;
参考文献
Guo, Song; Zhang, Hongli; Huang, Ling; Guo, Zhendong; Xiong, Guang; Zhao, Jianzhang
Chemical Communications, 2013 , vol. 49, # 77 p. 8689 - 8691
反应条件
dihydridotetrakis(triphenylphosphine)ruthenium(II); sodium hydride; acetonitrile; 1,3-diisopropylimidazolium bromide in toluene
24 h; Inert atmosphereReflux;
参考文献
Zhang, Jian; Senthilkumar, Muthaiah; Ghosh, Subhash Chandra; Hong, Soon Hyeok
Angewandte Chemie - International Edition, 2010 , vol. 49, # 36 p. 6391 - 6395
