S(-)-4-氯-3-羟基丁酸乙酯合成路线 （共 27 条）
反应条件
1: sodium hydroxide / ethanol / 15 h / 0 - 20 °C 2: triphenylphosphine; bromine / dichloromethane / 1.5 h / 0 °C View Scheme
参考文献
KOLON LIFE SCIENCE, INC.
Patent: US2012/46494 A1, 2012 ;
反应条件
Pseudomonas sp. DS-K-NR818 in water T=30°C; 40 h; pH 7.2; Title compound not separated from byproducts;
参考文献
Suzuki, Toshio; Idogaki, Hideaki; Kasai, Naoya
Tetrahedron Asymmetry, 1996 , vol. 7, # 11 p. 3109 - 3112
反应条件
hydrogenchloride; sodium hydroxide 1.) reflux, 1 h, 2.) reflux, 3 h; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Yuasa, Yoshifumi; Tsuruta, Haruki
Liebigs Annales, 1997 , # 9 p. 1877 - 1879
反应条件
Candida antarctica lipase; 4 Angstroems MS in 1,4-dioxane T=30°C; 24 h; other reaction time; Product distribution;
参考文献
Sanchez, Victor M.; Rebolledo, Francisca; Gotor, Vicente
Journal of Organic Chemistry, 1999 , vol. 64, # 2-5 p. 1464 - 1470
反应条件
hydrogenchloride; sodium hydroxide 1.) reflux, 1 h, 2.) reflux, 3 h; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Yuasa, Yoshifumi; Tsuruta, Haruki
Liebigs Annales, 1997 , # 9 p. 1877 - 1879
反应条件
Pseudomonas sp. DS-K-NR818 in water T=30°C; 40 h; pH 7.2; Title compound not separated from byproducts;
参考文献
Suzuki, Toshio; Idogaki, Hideaki; Kasai, Naoya
Tetrahedron Asymmetry, 1996 , vol. 7, # 11 p. 3109 - 3112
反应条件
hydrogenchloride; sodium hydroxide 1.) reflux, 1 h, 2.) reflux, 3 h; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Yuasa, Yoshifumi; Tsuruta, Haruki
Liebigs Annales, 1997 , # 9 p. 1877 - 1879
反应条件
ammonia in methanol T=70°C;
参考文献
Konda; Takahashi; Onda
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1083 - 1087
反应条件
Pseudomonas sp. DS-K-NR818 in water T=30°C; 40 h; pH 7.2; Title compound not separated from byproducts;
参考文献
Suzuki, Toshio; Idogaki, Hideaki; Kasai, Naoya
Tetrahedron Asymmetry, 1996 , vol. 7, # 11 p. 3109 - 3112
反应条件
hydrogenchloride; sodium hydroxide 1.) reflux, 1 h, 2.) reflux, 3 h; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Yuasa, Yoshifumi; Tsuruta, Haruki
Liebigs Annales, 1997 , # 9 p. 1877 - 1879
