1: 2-bromo-6-chloro-3-methylpyridine With n-butyllithium in tetrahydrofuran; hexanes T=-78 - 20°C; Inert atmosphere; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexanes T=-78 - 20°C; Inert atmosphere;

1: With n-butyllithium; 2-(dimethylamino)-ethanol in hexane T=0°C; 1 h; 2: With carbon tetrabromide in tetrahydrofuran; hexane T=-78°C; 1 h;

1.1: 2-dimethylaminoethanol; n-BuLi / hexane / 1 h / 0 °C 1.2: 70 percent / C2Cl6 / hexane; tetrahydrofuran / 1 h / 0 °C 2.1: 2-dimethylaminoethanol; n-BuLi / hexane / 1 h / 0 °C 2.2: 71 percent / CBr4 / hexane; tetrahydrofuran / 1 h / -78 °C View Scheme