2-二乙氨基氯乙烷盐酸盐合成路线 （共 91 条）
反应条件
potassium hydroxide; sodium hydride
1.) paraffinoel, toluol, reflux, 30 min; 2.) toluol, 0 deg C; Yield given. Multistep reaction;
参考文献
Franke, L.R. Rodriguez-Avial; Wolf, H.; Wray, V.
Tetrahedron, 1984 , vol. 40, # 18 p. 3491 - 3498
反应条件
methanol; sodium methylate; sodium iodide
参考文献
Burger et al.
Journal of the American Chemical Society, 1945 , vol. 67, p. 1416,1417
反应条件
1: potassium carbonate; potassium iodide / acetone / Heating
2: aq. sodium hydroxide; HCl / ethanol / 2 h / Heating
3: thionyl chloride / dimethylformamide / 3 h / Heating
View Scheme
参考文献
Das, Umashankar; Alcorn, Jane; Shrivastav, Anuraag; Sharma, Rajendra K.; De Clercq, Erik; Balzarini, Jan; Dimmock, Jonathan R.
European Journal of Medicinal Chemistry, 2007 , vol. 42, # 1 p. 71 - 80
反应条件
2: aq. HCl / Heating
View Scheme
参考文献
Villani; Tavares; Ellis
Journal of pharmaceutical sciences, 1969 , vol. 58, # 1 p. 138 - 140
反应条件
methanol; sodium methylate
参考文献
Chapman; Hager; Shay
Journal of the American Pharmaceutical Association (1912-1977), 1947 , vol. 36, p. 78,79
反应条件
potassium carbonate; acetone
参考文献
Kelly, Jane X.; Smilkstein, Martin J.; Cooper, Roland A.; Lane, Kristin D.; Johnson, Robert A.; Janowsky, Aaron; Dodean, Rozalia A.; Hinrichs, David J.; Winter, Rolf; Riscoe, Michael
Antimicrobial Agents and Chemotherapy, 2007 , vol. 51, # 11 p. 4133 - 4140
反应条件
potassium carbonate; acetone
参考文献
CIBA
Patent: US1941312 , 1930 ;
Full Text Show Details
CIBA
Patent: DE551029 , 1930 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 19, p. 1130,1131
Full Text Show Details
CIBA
Patent: CH150168 , 1929 ;
反应条件
1: With sodium hydroxide
T=120°C; 5 h;
2: in water
T=20°C;
参考文献
KYOWA HAKKO KOGYO CO., LTD.
Patent: EP1642880 A1, 2006 ;
Location in patent: Page/Page column 110 ;
反应条件
1: caesium carbonate / N,N-dimethyl-formamide / 2.5 h / 100 °C / |Inert atmosphere
2: hydrogen; 5 palladium on charcoal / methanol / 4 h / 20 °C
View Scheme
参考文献
Pan, Xiaoyan; Dong, Jinyun; Gao, Hongping; Wang, Fang; Zhang, Yanmin; Wang, Sicen; Zhang, Jie
Chemical Biology and Drug Design, 2014 , vol. 83, # 5 p. 592 - 599
反应条件
ethanol; sodium hydrogencarbonate
参考文献
Kotschetkow; Dudykina
Zhurnal Obshchei Khimii, 1959 , vol. 29, p. 1659,1662,1663; engl.Ausg.S.1635,1637,1638
