L-(+)-酒石酸二乙酯合成路线 （共 47 条）
反应条件
1: 1,3-dibromo-5,5-dimethyl-hydantoin; MeOAMVN / acetic acid / 3 h / 55 °C / light-shielding conditions 2: ammonium acetate / ethyl acetate; water; acetic acid / 3.5 h / 10 - 50 °C / light-shielding conditions View Scheme
参考文献
Daiichi Sankyo Company, Limited
Patent: EP2298763 A1, 2011 ;
EP 2298763 A1
反应条件
methyltrioxorhenium (VII); sodium sulfite T=150 - 160°C; 84 h; regiospecific reaction;
参考文献
Ahmad, Irshad; Chapman, Garry; Nicholas, Kenneth M.
Organometallics, 2011 , vol. 30, # 10 p. 2810 - 2818
反应条件
methanol; sodium hydroxide; water
参考文献
Bartoli, Enzo; Palmieri, Beniamino; Medici, Alessandro
Patent: US2005/113352 A1, 2005 ;
Location in patent: Page/Page column 2-3; 6 ;
参考文献
Patterson; Todd
Journal of the Chemical Society, 1929 , p. 1769
参考文献
Patterson; Thomson
Journal of the Chemical Society, 1929 , p. 1897
Full Text Show Details
Theilacker; Chou
Justus Liebigs Annalen der Chemie, 1936 , vol. 523, p. 148
反应条件
NaIO4 on SiO2 in dichloromethane T=20°C;
参考文献
Janthawornpong, Karnjapan; Krasutsky, Sergiy; Chaignon, Philippe; Rohmer, Michel; Poulter, C. Dale; Seemann, Myriam
Journal of the American Chemical Society, 2013 , vol. 135, # 5 p. 1816 - 1822
反应条件
potassium hydroxide in methanol
参考文献
Seebach,D. et al.
Helvetica Chimica Acta, 1977 , vol. 60, p. 301 - 325
参考文献
Patterson; Thomson
Journal of the Chemical Society, 1929 , p. 1897
Full Text Show Details
Theilacker; Chou
Justus Liebigs Annalen der Chemie, 1936 , vol. 523, p. 148
反应条件
titanium(IV) isopropylate; tert.-butylhydroperoxide in dichloromethane
T=-20°C; Oxidation; Sharpless; 42 h;
参考文献
Paju, Anne; Kanger, Tonis; Pehk, Tonis; Lopp, Margus
Tetrahedron Letters, 2000 , vol. 41, # 35 p. 6883 - 6887
反应条件
1: With titanium(IV) isopropylate; 4 A molecular sieve in dichloromethane
T=-20°C; 0.5 h;
2: With tert.-butylhydroperoxide in decane; dichloromethane
T=-20°C; 68 h; Further byproducts given;
参考文献
Paju, Anne; Kanger, Tonis; Pehk, Tonis; Lindmaa, Rasmus; Mueuerisepp, Aleksander-Mati; Lopp, Margus
Tetrahedron Asymmetry, 2003 , vol. 14, # 11 p. 1565 - 1573
