1-溴-3-甲基-2-丁烯合成路线 （共 689 条）
反应条件
n-butyllithium in tetrahydrofuran; N,N-dimethyl-formamide T=-78°C; 0.166667 h;
参考文献
Phytochemistry (Elsevier), , vol. 20, p. 647
反应条件
1: Mg, (iodomethane) 2: 1.) phenyllithium, 2.) cuprous iodide / 1.) ether, 1h, 25 deg C, 2.) ether, -78 deg C, 30 min 3: 2.) saturated aqueous NH4Cl / diethyl ether / 1.) -78 deg C, 4h, 2.) 0 deg C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 48, # 7 p. 1106 - 1107
反应条件
indium; methyllithium 1.) 1,4-dioxane, 2.) 0 deg C, 30 min; room temperature, 2 h, 3.) 1,4-dioxane, 0 deg C, 1 h, room temperature, 1 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 5 p. 549 - 552
反应条件
1: 3.18 g / K2CO3 / acetone / 4 h / Heating 2: 2.45 g / K2CO3 / acetone / 3 h / Heating 3: 1.03 g / methanolic KOH / ethanol / 72 h / Ambient temperature 4: 200 mg / dimethylaniline / 4 h / 185 °C 5: 100 mg / NaOH / ethanol / 0.02 h / Heating View Scheme
参考文献
Islam, Azizul; Hossain, M Amzad
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1993 , vol. 32, # 7 p. 713 - 715
反应条件
1: 1.) BuLi / 1.) THF, hexane, -60 deg C, 15 min; 2.) THF, hexane, -50 deg C, 1 h 2: 70 percent / diethyl ether / 3 h / 0 °C 3: 85 percent / NaH / tetrahydrofuran / 0 deg C, then Rt 1 h View Scheme
参考文献
Gebhard, R.; Courtin, J. M. L.; Shadid, J. B.; Haveren, J. van; Haeringen, C. J. van; Lugtenburg, J.
Recueil des Travaux Chimiques des Pays-Bas, 1989 , vol. 108, # 6 p. 207 - 214
反应条件
1.1: 86 percent / dimethylformamide / 48 h / 25 °C 2.1: 90 percent / aq. NaOH / methanol / 8 h / Heating 3.1: 85 percent / CBr4; PPh3; pyridine / CH2Cl2 4.1: tetrahydrofuran / 0.33 h / -20 °C 5.1: n-BuLi; t-BuOH / tetrahydrofuran; hexane / 0.33 h / -78 °C 5.2: 8 percent / tetrahydrofuran; hexane / 3 h 6.1: NaBH4 / methanol / 0.33 h / 0 °C 7.1: 254.8 mg / Et3N; DMAP / CH2Cl2 / 5 h / 25 °C 8.1: aq. CAN / acetonitrile / 0.25 h / 25 °C 8.2: aq. NaOH / 1 h / 25 °C View Scheme
参考文献
Couladouros, Elias A.; Strongilos, Alexandros T.; Papageorgiou, Vassilios P.; Plyta, Zoi F.
Chemistry - A European Journal, 2002 , vol. 8, # 8 p. 1795 - 1803
反应条件
chromium dichloride; lithium iodide in tetrahydrofuran T=55°C; Hiyama-Nozaki reaction; 3 h;
参考文献
Schrekker, Henri S.; De Bolster, Martin W. G.; Orru, Romano V. A.; Wessjohann, Ludger A.
Journal of Organic Chemistry, 2002 , vol. 67, # 7 p. 1975 - 1981
反应条件
copper(l) iodide; boron trifluoride diethyl etherate in diethyl ether other Lewis acids, solvents; Product distribution;
参考文献
Journal of the American Chemical Society, , vol. 102, # 7 p. 2318 - 2325
参考文献
Lewina et al.
Sb. Statei Obshch. Khim., 1953 , p. 355,359
Chem.Abstr., 1955 , p. 829
反应条件
potassium carbonate in N,N-dimethyl-formamide T=0°C;
参考文献
Cushing, Timothy D.; Sanz-Cervera, Juan F.; Williams, Robert M.
Journal of the American Chemical Society, 1996 , vol. 118, # 3 p. 557 - 579
