1-溴-3-甲基-2-丁烯合成路线 （共 689 条）
反应条件
potassium hydroxide in water
T=0 - 25°C; Alkylation; 13 h;
参考文献
Tan, Wenfei; Li, Wei-Dong Z.; Huang, Chusheng; Li, Yulin; Xing, Yacheng
Synthetic Communications, 1999 , vol. 29, # 19 p. 3369 - 3377
反应条件
potassium hydroxide in water
T=20°C; Inert atmosphere;
参考文献
Grealis, John P.; Mueller-Bunz, Helge; Ortin, Yannick; Casey, Michael; McGlinchey, Michael J.
European Journal of Organic Chemistry, 2013 , # 2 p. 332 - 347
反应条件
sodium methylate in methanol
参考文献
Barua, P.; Barua, N. C.; Sharma, R.P.
Tetrahedron Letters, 1983 , vol. 24, # 51 p. 5801 - 5804
反应条件
1: 1-(2,4-dihydroxy-phenyl)-ethanone With sodium hydroxide in acetone
2: prenyl bromide in acetone; benzene
Heating; Further stages.;
参考文献
Dong, Xiaowu; Fan, Yongjian; Yu, Lingjun; Hu, Yongzhou
Archiv der Pharmazie, 2007 , vol. 340, # 7 p. 372 - 376
反应条件
1: NaOMe / methanol
2: formic acid
3: 60 percent / DDQ
View Scheme
参考文献
Barua, P.; Barua, N. C.; Sharma, R.P.
Tetrahedron Letters, 1983 , vol. 24, # 51 p. 5801 - 5804
反应条件
1: 1.) CH3Li, t-butyllithium, 2.) tetrakis<iodo(tributylphosphine)copper(I)> / 1.) THF, -78 deg C, 1 min, 2.) THF, - 78 deg C, 5 min
2: 89 percent / KOH / methanol / 1 h / Heating
3: 1.) Hg(OAc)2, 2.) NaBH4, NaOH / 1.) methanol, 10 min, 2.) methanol, 1 min
View Scheme
参考文献
Raner, Kevin D.; Ward, A. David
Australian Journal of Chemistry, 1991 , vol. 44, # 12 p. 1749 - 1760
反应条件
aluminium trichloride; zinc in tetrahydrofuran
4 h; Ambient temperature;
参考文献
Kitsos-Rzychon, Beate; Eilbracht, Peter
Tetrahedron, 1998 , vol. 54, # 36 p. 10721 - 10732
反应条件
indium in tetrahydrofuran; water
T=20°C; 168 h;
参考文献
Kwon, Jin Sun; Pae, Ae Nim; Choi, Kyung Il; Koh, Hun Yeong; Kim, Youseung; Cho, Yong Seo
Tetrahedron Letters, 2001 , vol. 42, # 10 p. 1957 - 1959
反应条件
sodium hydride in ethylene glycol dimethyl ether
a) 0 deg C, 1 h, b) RT, 16 h;
参考文献
Pace, Vittorio; Castoldi, Laura; Holzer, Wolfgang
Tetrahedron Letters, 2012 , vol. 53, # 8 p. 967 - 972
反应条件
1: thiophenol With sodium hydroxide in dimethyl sulfoxide
T=60 - 65°C; 1.5 h;
2: prenyl bromide in dimethyl sulfoxide
T=60 - 65°C; 20.75 h; Product distribution / selectivity;
参考文献
SUN PHARMACEUTICAL INDUSTRIES LIMITED
Patent: WO2006/59345 A2, 2006 ;
Location in patent: Page/Page column 17-18 ;
