1-溴-3-甲基-2-丁烯合成路线 （共 689 条）
反应条件
1: 1-(2,4-dihydroxy-phenyl)-ethanone With sodium hydroxide in acetone
2: prenyl bromide in acetone; benzene
Heating; Further stages.;
参考文献
Dong, Xiaowu; Fan, Yongjian; Yu, Lingjun; Hu, Yongzhou
Archiv der Pharmazie, 2007 , vol. 340, # 7 p. 372 - 376
反应条件
1: KOt-Bu; O2 / tetrahydrofuran
View Scheme
参考文献
Cardoso; Srinivasan, Natarajan; Lobo, Ana M; Prabhakar, Sundaresan
Tetrahedron Letters, 2001 , vol. 42, # 38 p. 6663 - 6666
反应条件
1: 1.) MeLi, 2.) HMPA, 3.) CSA
2: 49 percent / Et3N / CH2Cl2 / 0.25 h / 0 °C
3: 95 percent / H2 / 10percent Pd/C / tetrahydrofuran / 24 h / 760 Torr
4: 1.) MsCl, Et3N, 2.) TBAF / 1.) CH2Cl2, 0 deg C, 30 min, 2.) CH2Cl2, THF, RT, 15 h
View Scheme
参考文献
Friesen; Giroux
Canadian Journal of Chemistry, 1994 , vol. 72, # 8 p. 1857 - 1865
反应条件
triethylamine in ethanol
17 h; Heating;
参考文献
Yamane; Hashizume; Yamashita; Konishi; Hosoe; Hidaka; Watanabe; Kawaharada; Yamamoto; Kuze
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 1 p. 148 - 155
反应条件
dipotassium hydrogenphosphate; zinc in water; acetonitrile
1 h;
参考文献
Bieber, Lothar W.; De Sa, Ana C.P.F.; Menezes, Paulo H.; Goncalves, Simone M.C.
Tetrahedron Letters, 2001 , vol. 42, # 28 p. 4597 - 4599
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; n-butyllithium in tetrahydrofuran; hexane
1.) -78 deg C, 30 min, 2.) room temp, 20 h; Title compound not separated from byproducts;
参考文献
Goldsmith, David J.; Liotta, Dennis C.; Volmer, Mark; Hoekstra, William; Waykole, Liladhar
Tetrahedron, 1985 , vol. 41, # 21 p. 4873 - 4880
反应条件
1: cyclohexanone With sodium hexamethyldisilazane in tetrahydrofuran
T=-78°C; 0.5 h; Inert atmosphere;
2: prenyl bromide in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
参考文献
Li, Zhilong; Jung, Heejung; Park, Mira; Lah, Myoung Soo; Koo, Sangho
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 11-12 p. 1913 - 1917
反应条件
1.1: (iPr)2NLi / tetrahydrofuran; hexane / -78 - 20 °C
1.2: tetrahydrofuran; hexane / 12 h / 20 °C
2.1: 7.0 g / NaIO4; phosphate buffer / H2O / 15 h / 20 °C / pH 7.0
View Scheme
参考文献
Evans, Elizabeth H.; Hewson, Alan T.; March, Lorraine A.; Nowell, Ian W.; Wadsworth, Alan H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 137 - 150
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=40°C; 8 h;
参考文献
Pisco, Laura; Kordian, Marcus; Peseke, Klaus; Feist, Holger; Michalik, Dirk; Estrada, Ernesto; Carvalho, Joao; Hamilton, Gerhard; Rando, Daniela; Quincoces, Jose
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 3 p. 401 - 407
反应条件
sodium hydride
1.) DMSO, 1 h, room temp.; 2.) DMSO, 24 h, room temp.; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Appendino, Giovanni; Tagliapietra, Silvia; Cravotto, Giancarlo; Nano, Gian Mario
Gazzetta Chimica Italiana, 1989 , vol. 119, # 7 p. 385 - 388
