1-溴-3-甲基-2-丁烯合成路线 （共 689 条）
参考文献
Riedl
Chemische Berichte, 1952 , vol. 85, p. 692,704, 708
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Riedl; Huebner
Chemische Berichte, 1957 , vol. 90, p. 2870,2875
参考文献
Riedl
Chemische Berichte, 1952 , vol. 85, p. 692,704, 708
Full Text Show Details
Riedl; Huebner
Chemische Berichte, 1957 , vol. 90, p. 2870,2875
反应条件
1: 4-hydroxy-benzaldehyde With potassium hydroxide in water
T=20°C;
2: prenyl bromide With potassium hydroxide in water
T=30°C; 48 h;
3: With acetic acid in water
pH=5;
参考文献
Rao, Gudapati Venkateswara; Swamy, Badrappa Narayana; Chandregowda, Venkateshappa; Reddy, G. Chandrasekara
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 5 p. 2239 - 2245
反应条件
barium orthoaluminate
T=20°C; Product distribution / selectivity;
参考文献
PURDUE RESEARCH FOUNDATION
Patent: WO2008/76767 A1, 2008 ;
Location in patent: Page/Page column 19 ;
反应条件
(i) nBuLi, Me2NCH2CH2NMe2, (ii) /BRN= 1420778/, (iii) /BRN= 969135/; Multistep reaction;
参考文献
Shen,C.C.; Ainsworth,C.
Tetrahedron Letters, 1979 , p. 83 - 86
反应条件
1: phloroglucinol trimethyl ether With n-butyllithium in hexane; cyclohexane
0.5 h; Heating;
2: prenyl bromide in hexane; cyclohexane
2 h; Heating;
参考文献
Gulacsi, Katalin; Litkei, Gyoergy; Antus, Sandor; Szantay, Csaba; Darko, Laszlo L.; Szelenyi, Judith; Hasko, Gyoergy; Vizi, Szilveszter E.
Archiv der Pharmazie, 2001 , vol. 334, # 2 p. 53 - 61
反应条件
1: NaH, n-BuLi
2: NaH / diethyl ether / 2 h / 0 - 25 °C
3: 75 percent / Mg, Ni(II)-bisacetilacetonate / diethyl ether / 16 h / Heating
4: 10 percent / BF3*Et2O, CH3COOH / CH2Cl2 / 3 h / 25 °C
View Scheme
参考文献
Armstrong, Rosemary J.; Weiler, Larry
Canadian Journal of Chemistry, 1983 , vol. 61, p. 2530 - 2539
反应条件
1.1: copper(I) iodide; LDA / tetrahydrofuran; hexane / 2 h / -110 - -30 °C
1.2: 73 percent / tetrahydrofuran; hexane / 1 h / -30 °C
2.1: 98 percent / aq. NaOH / ethanol / 6 h / Heating
View Scheme
参考文献
Cocker, Wesley; Geraghty, Niall W. A.; McMurry, T. Brian H.; Shannon, Patrick V. R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 10 p. 2245 - 2254
反应条件
n-butyllithium; sodium hydride; diisopropylamine
1.) THF, 0 deg C and reflux, 15 min, 2.) THF, HMPA, 0 deg C, 15 min and 35 deg C 30 min, 3.) THF, HMPA, 0 deg C and 3 h, 25 deg C; Yield given. Multistep reaction;
参考文献
Curran, Dennis P.; Yu, Hosung; Liu, Hongtao
Tetrahedron, 1994 , vol. 50, # 25 p. 7343 - 7366
反应条件
sodium hydride in toluene
T=15°C; 24 h;
参考文献
Wang, Yang; Wu, Jiang; Xia, Peng
Synthetic Communications, 2006 , vol. 36, # 18 p. 2685 - 2698
