sodium t-butanolate in toluene T=-13°C; 2.61667 h; Product distribution / selectivity;

1: With p-methylbenzenesulfonyl (tosylate); p-toluenesulfonic acid sodium salt in toluene T=100°C; 36 h; 2: With sodium hydroxide; water in tetrahydrofuran; toluene T=20°C; 0.05 h; Product distribution / selectivity;

sodium hydride in N,N-dimethyl-formamide T=0 - 20°C;

1: With sodium tetrahydroborate in isopropyl alcohol T=20°C; 12 h; 2: With water in isopropyl alcohol; toluene Product distribution / selectivity;

1: 1-[(S)-1-(4-fluorophenyl)ethyl]piperidin-2-one With n-butyllithium; diisopropylamine in tetrahydrofuran; cyclohexane; toluene T=-20°C; 1.76667 - 148 h; 2: 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde in tetrahydrofuran; cyclohexane; toluene T=-20°C; 1.66667 - 2.66667 h; 3: With acetic anhydride; sodium t-butanolate Product distribution / selectivity; more than 3 stages;

1: 1-[(S)-1-(4-fluorophenyl)ethyl]piperidin-2-one With lithium diisopropyl amide in tetrahydrofuran; cyclohexane T=-70°C; 1 h; 2: diethyl chlorophosphate in tetrahydrofuran; cyclohexane T=-70°C; 1 h; 3: 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde With lithium diisopropyl amide Product distribution / selectivity; more than 3 stages;

sodium methylate in tetrahydrofuran; methanol T=0 - 20°C; 0.583333 h; Product distribution / selectivity;

lithium hydroxide in tetrahydrofuran; ethanol T=20°C; 18 h; Product distribution / selectivity;

triethylamine in ethanol T=50 - 70°C; 23 h; Product distribution / selectivity;

piperidine; pyridine T=65°C; 20 - 25 h; Product distribution / selectivity;