反应条件
1: thien-3-yl bromide With isopropylmagnesium chloride in tetrahydrofuran T=25 - 40°C; 3 h; Inert atmosphereLarge scale; 2: (S)-2-methyl-3,4,5,6-tetrahydro-2H-pyran-4-one T=-15 - 10°C; 0.666667 h; Inert atmosphereLarge scale; Overall yield = 90.4 percent; Overall yield = 47.1 kg;
参考文献
Alcaraz, Marie-Lyne; Atkinson, Stephanie; Cornwall, Philip; Foster, Alison C.; Gill, Duncan M.; Humphries, Lesley A.; Keegan, Philip S.; Kemp, Richard; Merifield, Eric; Nixon, Robert A.; Noble, Allison J.; O'Beirne, Darren; Patel, Zakariya M.; Perkins, Jacob; Rowan, Paul; Sadler, Paul; Singleton, John T.; Tornos, James; Watts, Andrew J.; Woodland, Ian A.
Organic Process Research and Development, 2005 , vol. 9, # 5 p. 555 - 569
