2-[(2-氨基苯基)氨基]-5-甲基-3-噻吩甲腈合成路线 （共 9 条）
反应条件
acetic acid T=120°C; Product distribution / selectivity;
参考文献
Shastri, Jwalant Ashesh; Bhatnagar, Akshat; Thaper, Rajesh Kumar; Dubey, Sushil Kumar
Patent: US2009/5556 A1, 2009 ;
Location in patent: Page/Page column 5 ;
参考文献
Panchasara, Dinesh; Gupta, Poorvi; Kaushik, Geetesh; Dubey, Sushil
Patent: US2010/317849 A1, 2010 ;
Location in patent: Page/Page column 4 ;
反应条件
hydrogen in mesytilene T=140°C; 16 h;
参考文献
Tetrahedron, , vol. 66, # 41 p. 8203 - 8209
反应条件
T=120°C; Product distribution / selectivity;
参考文献
Shastri, Jwalant Ashesh; Bhatnagar, Akshat; Thaper, Rajesh Kumar; Dubey, Sushil Kumar
Patent: US2009/5556 A1, 2009 ;
Location in patent: Page/Page column 5 ;
反应条件
triethylsilane; palladium 10 on activated carbon in water; ethyl acetate
T=40°C; TemperatureTimeSolvent;
参考文献
Hartwig, Jan; Ceylan, Sascha; Kupracz, Lukas; Coutable, Ludovic; Kirschning, Andreas
Angewandte Chemie - International Edition, 2013 , vol. 52, # 37 p. 9813 - 9817
Angew. Chem., 2013 , vol. 125, # 37 p. 9995 - 9999,5
反应条件
1: 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; tetra-n-butylammonium acetate; tris(dibenzylideneacetone)dipalladium(0) chloroform complex / ethyl acetate / 50 °C
2: triethylsilane; palladium 10 on activated carbon / ethyl acetate; water / 40 °C
View Scheme
参考文献
Hartwig, Jan; Ceylan, Sascha; Kupracz, Lukas; Coutable, Ludovic; Kirschning, Andreas
Angewandte Chemie - International Edition, 2013 , vol. 52, # 37 p. 9813 - 9817
Angew. Chem., 2013 , vol. 125, # 37 p. 9995 - 9999,5
反应条件
hydrogen in mesytilene
T=140°C; 48 h; chemoselective reaction;
参考文献
Leyva-Perez, Antonio; Cabrero-Antonino, Jose R.; Corma, Avelino
Tetrahedron, 2010 , vol. 66, # 41 p. 8203 - 8209
反应条件
1: 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; tetra-n-butylammonium acetate; tris(dibenzylideneacetone)dipalladium(0) chloroform complex / ethyl acetate / 50 °C
2: triethylsilane; palladium 10 on activated carbon / ethyl acetate; water / 40 °C
View Scheme
参考文献
Hartwig, Jan; Ceylan, Sascha; Kupracz, Lukas; Coutable, Ludovic; Kirschning, Andreas
Angewandte Chemie - International Edition, 2013 , vol. 52, # 37 p. 9813 - 9817
Angew. Chem., 2013 , vol. 125, # 37 p. 9995 - 9999,5
反应条件
hydrogenchloride in isopropyl alcohol
参考文献
JANSSEN PHARMACEUTICA NV; ORTHO-CLINICAL DIAGNOSTICS, INC; DONAHUE, Matthew Garrett; GONG, Yong; SALTER, Rhys; HRYHORENKO, Eric; DECORY, Thomas R.; REMMERIE, Bart M.; SANKARAN, Banumathi
Patent: WO2014/31587 A1, 2014 ;
Location in patent: Page/Page column 58 ;
