3-溴-6-甲基-5-硝基-2(1h)-吡啶酮合成路线 （共 7 条）
反应条件
1: With nitric acid in water
T=0 - 20°C; 3.5 h;
2: With sodium hydroxide in water; ethyl acetate
pH=4;
参考文献
SYNGENTA PARTICIPATIONS AG; SYNGENTA LIMITED
Patent: WO2008/101682 A2, 2008 ;
Location in patent: Page/Page column 42 ;
参考文献
Brown; Burke
Journal of the American Chemical Society, 1955 , vol. 77, p. 6053
反应条件
hydrogenchloride; sodium nitrite
Diazotization;
参考文献
Parker; Shive
Journal of the American Chemical Society, 1947 , vol. 69, p. 63,66
反应条件
1: liquid NH3; xylene; Fe(NO3)3
2: concentrated H2SO4; concentrated HNO3
3: acetic acid; bromine
4: sodium nitrite; concentrated aqueous hydrochloric acid / Diazotization
View Scheme
参考文献
Parker; Shive
Journal of the American Chemical Society, 1947 , vol. 69, p. 63,66
反应条件
1: concentrated H2SO4; concentrated HNO3
2: acetic acid; bromine
3: sodium nitrite; concentrated aqueous hydrochloric acid / Diazotization
View Scheme
参考文献
Parker; Shive
Journal of the American Chemical Society, 1947 , vol. 69, p. 63,66
反应条件
1: acetic acid; bromine
2: sodium nitrite; concentrated aqueous hydrochloric acid / Diazotization
View Scheme
参考文献
Parker; Shive
Journal of the American Chemical Society, 1947 , vol. 69, p. 63,66
反应条件
trichlorophosphate
7 h; Heating / reflux;
参考文献
SYNGENTA PARTICIPATIONS AG; SYNGENTA LIMITED
Patent: WO2008/101682 A2, 2008 ;
Location in patent: Page/Page column 42-43 ;
