N,N-二乙基氯甲酰胺合成路线 （共 193 条）
反应条件
1: 2-methylbenzenethiol With sodium hydride in tetrahydrofuran
T=20°C; 1 h;
2: N,N-diethyl carbamoyl chloride in tetrahydrofuran
T=0°C;
参考文献
Kamila, Sukanta; Biehl, Edward R.
Heterocycles, 2004 , vol. 63, # 8 p. 1813 - 1819
反应条件
tert.-butyl lithium
1.) hexane, THF, -78 deg C, 5 min, 2.) hexane, THF, RT, 24 h; Yield given. Multistep reaction;
参考文献
Cambie, Richard C.; Higgs, Paul I.; Lee, Kee Chee; Metzler, Michael R.; Rutledge, Peter S.; at al.
Australian Journal of Chemistry, 1991 , vol. 44, # 10 p. 1465 - 1477
反应条件
1.1: 95 percent / pyridine / 36 h / 100 °C
2.1: i-Pr2NH; n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C
2.2: 70 percent / iodine / tetrahydrofuran; hexane / 0.25 h / cooling
View Scheme
参考文献
Blakemore, Paul R.; Kilner, Colin; Milicevic, Selena D.
Journal of Organic Chemistry, 2005 , vol. 70, # 1 p. 373 - 376
反应条件
N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium
1) THF, cyclohexane, -78 deg C, 1 h, 2) to room temperature, 12 h; Yield given. Multistep reaction;
参考文献
De Silva; Reed; Billedeau; Wang; Norris; Snieckus
Tetrahedron, 1992 , vol. 48, # 23 p. 4863 - 4878
反应条件
dimethylsulfide; triethylamine; copper(I) bromide; bis-triphenylphosphine-palladium(II) chloride
Heating;
参考文献
Concellon, Jose M.; Rodriguez-Solla, Humberto; Concellon, Carmen
Tetrahedron Letters, 2004 , vol. 45, # 10 p. 2129 - 2131
反应条件
1: 4-methoxy-phenol With sodium hydride in ethylene glycol dimethyl ether; mineral oil
T=0 - 23°C; 0.166667 h;
2: N,N-diethyl carbamoyl chloride in ethylene glycol dimethyl ether; mineral oil
T=23°C; 11 h;
参考文献
Quasdorf, Kyle W.; Riener, Michelle; Petrova, Krastina V.; Garg, Neil K.
Journal of the American Chemical Society, 2009 , vol. 131, # 49 p. 17748 - 17749
反应条件
pyridine
6 h; Heating;
参考文献
Jutand, Anny; Mosleh, Adil
Journal of Organic Chemistry, 1997 , vol. 62, # 2 p. 261 - 274
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C
1.2: 89 percent / hexane; tetrahydrofuran / 36 h / Heating
2.1: s-BuLi; TMEDA / cyclohexane; hexane; tetrahydrofuran / 2 h / -78 °C
2.2: 88 percent / iodine / tetrahydrofuran; hexane; cyclohexane / -78 - 20 °C
View Scheme
参考文献
Sanz, Roberto; Castroviejo, M. Pilar; Fernandez, Yolanda; Fananas, Francisco J.
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6548 - 6551
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C
1.2: 89 percent / hexane; tetrahydrofuran / 36 h / Heating
2.1: s-BuLi; TMEDA / cyclohexane; hexane; tetrahydrofuran / 2 h / -78 °C
2.2: 84 percent / 1,2-dibromo-1,1,2,2-tetrachloroethane / tetrahydrofuran; hexane; cyclohexane / -78 - 20 °C
View Scheme
参考文献
Sanz, Roberto; Castroviejo, M. Pilar; Fernandez, Yolanda; Fananas, Francisco J.
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6548 - 6551
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C
1.2: 89 percent / hexane; tetrahydrofuran / 36 h / Heating
2.1: s-BuLi; TMEDA / cyclohexane; hexane; tetrahydrofuran / 2 h / -78 °C
2.2: 83 percent / hexachloroethane / tetrahydrofuran; hexane; cyclohexane / -78 - 20 °C
View Scheme
参考文献
Sanz, Roberto; Castroviejo, M. Pilar; Fernandez, Yolanda; Fananas, Francisco J.
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6548 - 6551
