N,N-二乙基氯甲酰胺合成路线 （共 193 条）
反应条件
1.1: N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran / 1.25 h / -78 °C / Inert atmosphere
1.2: 1.17 h / -78 °C / Inert atmosphere
2.1: Ni(PCy3)2Cl2; K3PO4; 1,1,3,3-tetramethyldisiloxane / toluene / 15 h / 120 °C / Inert atmosphere
View Scheme
参考文献
Mesganaw, Tehetena; Fine Nathel, Noah F.; Garg, Neil K.
Organic Letters, 2012 , vol. 14, # 11 p. 2918 - 2921
反应条件
1: NaH / toluene / Ambient temperature
2: 83 percent / ethanol / 40 °C
View Scheme
参考文献
Sokilde, Birgitte; Mikkelsen, Ivan; Stensbol, Tine B.; Andersen, Birgit; Ebdrup, Soren; Krogsgaard-Larsen, Povl; Falch, Erik
Archiv der Pharmazie, 1996 , vol. 329, # 2 p. 95 - 104
反应条件
in chloroform
Heating;
参考文献
Mehta,S.J.; Hamor,G.H.
Journal of Pharmaceutical Sciences, 1961 , vol. 50, p. 672 - 675
反应条件
in chloroform
Heating;
参考文献
Mehta,S.J.; Hamor,G.H.
Journal of Pharmaceutical Sciences, 1961 , vol. 50, p. 672 - 675
反应条件
tin(IV) chloride
T=130 - 140°C; 10 h; var. solvents, other reagent - AlCl3, var. temperatures; Product distribution;
参考文献
Isakova, A. P.; Naumov, Yu. A.; Nikeryasova, S. V.; Fomichev, A. A.; Murugova, L. A.
Journal of Organic Chemistry USSR (English Translation), 1980 , vol. 16, # 3 p. 558 - 561
Zhurnal Organicheskoi Khimii, 1980 , vol. 16, # 3 p. 639 - 642
参考文献
Geigy A.G.
Patent: CH242949 , 1942 ;
反应条件
1: 100 percent / NaH / various solvent(s); tetrahydrofuran / 20 °C
2: 84 percent / tert-butyllithium / hexane; tetrahydrofuran / 3 h / -78 °C
View Scheme
参考文献
Hartung, Christian G.; Fecher, Anja; Chapell, Brian; Snieckus, Victor
Organic Letters, 2003 , vol. 5, # 11 p. 1899 - 1902
参考文献
Shionogi and Co., Ltd.
Patent: US4183856 A1, 1980 ;
反应条件
pyridine in dichloromethane
Heating;
参考文献
Maggi, Raimondo; Schlosser, Manfred
Journal of Organic Chemistry, 1996 , vol. 61, # 16 p. 5430 - 5434
反应条件
1: 67 percent / n-butyllithium / tetrahydrofuran; hexane / -78 °C
2: 3N HCl / tetrahydrofuran; hexane / Ambient temperature
View Scheme
参考文献
Blanchard, Christiane; Vaultier, Michel; Mortier, Jacques
Tetrahedron Letters, 1997 , vol. 38, # 51 p. 8863 - 8866
