2-乙酰氨基-4-溴苯甲醚合成路线 （共 8 条）
参考文献
Madesani
Gazzetta Chimica Italiana, 1932 , vol. 62, p. 51,54
反应条件
potassium acetate; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) in ethylene glycol dimethyl ether T=150°C;
参考文献
HEPTARES THERAPEUTICS LIMITED; CONGREVE, Miles Stuart; ANDREWS, Stephen Philippe; MASON, Jonathan Stephen; RICHARDSON, Christine Mary; BROWN, Giles Albert
Patent: WO2011/95625 A1, 2011 ;
Location in patent: Page/Page column 202 ;
WO 2011/095625 A1
反应条件
1: N-acetyl-2-amino-4-bromophenol With potassium carbonate in N,N-dimethyl-formamide
T=70°C; 0.5 h;
2: methyl iodide in N,N-dimethyl-formamide
T=60°C; 16 h;
参考文献
HEPTARES THERAPEUTICS LIMITED; CONGREVE, Miles Stuart; ANDREWS, Stephen Philippe; MASON, Jonathan Stephen; RICHARDSON, Christine Mary; BROWN, Giles Albert
Patent: WO2011/95625 A1, 2011 ;
Location in patent: Page/Page column 202 ;
WO 2011/095625 A1
反应条件
1.1: triethylamine / dichloromethane / 0.08 h / 10 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 70 °C
2.2: 16 h / 60 °C
View Scheme
参考文献
HEPTARES THERAPEUTICS LIMITED; CONGREVE, Miles Stuart; ANDREWS, Stephen Philippe; MASON, Jonathan Stephen; RICHARDSON, Christine Mary; BROWN, Giles Albert
Patent: WO2011/95625 A1, 2011 ;
WO 2011/095625 A1
参考文献
Kohn; Krasso
Journal of Organic Chemistry, 1948 , vol. 13, p. 329
反应条件
bromine; acetic acid
参考文献
Madesani
Gazzetta Chimica Italiana, 1932 , vol. 62, p. 51,54
反应条件
bromine; acetic acid
参考文献
Bell
Journal of the Chemical Society, 1960 , p. 769,771
参考文献
Madesani
Gazzetta Chimica Italiana, 1932 , vol. 62, p. 51,54
