(S)-3-(3-甲氧基苯基)哌啶合成路线 （共 16 条）
反应条件
hydrogen; ammonium formate; palladium on activated charcoal in methanol
1 h; Heating / reflux;
参考文献
ALLBAY AB
Patent: WO2008/127188 A1, 2008 ;
Location in patent: Page/Page column 25 ;
WO 2008/127188 A1
反应条件
carbon dioxide in methanol
T=30°C; P=75007.5 Torr; Resolution of racemateInert atmosphere;
参考文献
F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BROTHERTON-PLEISS, Christine E.; CHEN, Zhi; ERICKSON, Shawn David; KIM, Kyungjin; LI, Hongju; LOVEY, Allen John; QIAN, Yimin; SO, Sung-Sau; WOVKULICH, Peter Michael; YI, Lin
Patent: WO2014/60341 A1, 2014 ;
Location in patent: Paragraph 0085 ;
反应条件
trifluoroacetic acid in dichloromethane
T=20°C; 0.25 h;
参考文献
Amat, Mercedes; Canto, Margalida; Llor, Nuria; Escolano, Carmen; Molins, Elies; Espinosa, Enrique; Bosch, Joan
Journal of Organic Chemistry, 2002 , vol. 67, # 15 p. 5343 - 5351
反应条件
1.1: Na2CO3; 4 Angstroem molecular sieves / 2 h / 0 °C
2.1: 4 Angstroem molecular sieves / ethanol / 14 h / 80 °C
2.2: 37 percent / acetic acid; water / ethanol / 3 h / 80 °C
3.1: 59 percent / toluene / 24 h / Heating
4.1: 78 percent / LiAlH4; AlCl3 / tetrahydrofuran / 3.5 h / -78 - 20 °C
5.1: 71 percent / hydrogen / Pd(OH)2/C / ethyl acetate / 15 h / 20 °C
6.1: 60 percent / TFA / CH2Cl2 / 0.25 h / 20 °C
View Scheme
参考文献
Amat, Mercedes; Canto, Margalida; Llor, Nuria; Escolano, Carmen; Molins, Elies; Espinosa, Enrique; Bosch, Joan
Journal of Organic Chemistry, 2002 , vol. 67, # 15 p. 5343 - 5351
反应条件
1.1: 4 Angstroem molecular sieves / ethanol / 14 h / 80 °C
1.2: 37 percent / acetic acid; water / ethanol / 3 h / 80 °C
2.1: 59 percent / toluene / 24 h / Heating
3.1: 78 percent / LiAlH4; AlCl3 / tetrahydrofuran / 3.5 h / -78 - 20 °C
4.1: 71 percent / hydrogen / Pd(OH)2/C / ethyl acetate / 15 h / 20 °C
5.1: 60 percent / TFA / CH2Cl2 / 0.25 h / 20 °C
View Scheme
参考文献
Amat, Mercedes; Canto, Margalida; Llor, Nuria; Escolano, Carmen; Molins, Elies; Espinosa, Enrique; Bosch, Joan
Journal of Organic Chemistry, 2002 , vol. 67, # 15 p. 5343 - 5351
反应条件
1: 59 percent / toluene / 24 h / Heating
2: 78 percent / LiAlH4; AlCl3 / tetrahydrofuran / 3.5 h / -78 - 20 °C
3: 71 percent / hydrogen / Pd(OH)2/C / ethyl acetate / 15 h / 20 °C
4: 60 percent / TFA / CH2Cl2 / 0.25 h / 20 °C
View Scheme
参考文献
Amat, Mercedes; Canto, Margalida; Llor, Nuria; Escolano, Carmen; Molins, Elies; Espinosa, Enrique; Bosch, Joan
Journal of Organic Chemistry, 2002 , vol. 67, # 15 p. 5343 - 5351
反应条件
1: 78 percent / LiAlH4; AlCl3 / tetrahydrofuran / 3.5 h / -78 - 20 °C
2: 71 percent / hydrogen / Pd(OH)2/C / ethyl acetate / 15 h / 20 °C
3: 60 percent / TFA / CH2Cl2 / 0.25 h / 20 °C
View Scheme
参考文献
Amat, Mercedes; Canto, Margalida; Llor, Nuria; Escolano, Carmen; Molins, Elies; Espinosa, Enrique; Bosch, Joan
Journal of Organic Chemistry, 2002 , vol. 67, # 15 p. 5343 - 5351
反应条件
1: 71 percent / hydrogen / Pd(OH)2/C / ethyl acetate / 15 h / 20 °C
2: 60 percent / TFA / CH2Cl2 / 0.25 h / 20 °C
View Scheme
参考文献
Amat, Mercedes; Canto, Margalida; Llor, Nuria; Escolano, Carmen; Molins, Elies; Espinosa, Enrique; Bosch, Joan
Journal of Organic Chemistry, 2002 , vol. 67, # 15 p. 5343 - 5351
反应条件
1: 76.2 percent / <(C6H5)3P>2NiCl2
2: 90.7 percent / H2, concd. HCl / PtO2 / methanol / 3 h / 2844.3 Torr
View Scheme
参考文献
Grayson, Neile A.; Bowen, Wayne D.; Rice, Kenner C.
Heterocycles, 1992 , vol. 34, # 12 p. 2281 - 2292
反应条件
1: 90.7 percent / H2, concd. HCl / PtO2 / methanol / 3 h / 2844.3 Torr
View Scheme
参考文献
Grayson, Neile A.; Bowen, Wayne D.; Rice, Kenner C.
Heterocycles, 1992 , vol. 34, # 12 p. 2281 - 2292
