4,5,6,7-四氢-3-三氟甲基-2H-吲唑合成路线 （共 7 条）
反应条件
water; sodium hydroxide in ethanol T=120°C; 1 h; Microwave irradiationSealed tube;
参考文献
Ermolenko, Mikhail S.; Guillou, Sandrine; Janin, Yves L.
Tetrahedron, 2013 , vol. 69, # 1 p. 257 - 263
反应条件
1: With NH2NH2•xH2O in ethanol
Reflux;
2: With hydrogenchloride; water
0.0166667 h; Reflux;
参考文献
Ermolenko, Mikhail S.; Guillou, Sandrine; Janin, Yves L.
Tetrahedron, 2013 , vol. 69, # 1 p. 257 - 263
反应条件
1: With triethylamine in dichloromethane
T=0 - 20°C;
2: With NH2NH2•xH2O in ethanol
T=0°C; Reflux;
参考文献
Ermolenko, Mikhail S.; Guillou, Sandrine; Janin, Yves L.
Tetrahedron, 2013 , vol. 69, # 1 p. 257 - 263
反应条件
1: cyclohexanone With lithium hexamethyldisilazane in tetrahydrofuran
T=0°C; 0.25 h;
2: trifluoroacetic acid-p-nitrophenyl-ester in tetrahydrofuran
T=0°C; 1 h;
3: With hydrazine in tetrahydrofuran
T=65°C; 18 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/17932 A2, 2008 ;
Location in patent: Page/Page column 82-83 ;
反应条件
hydrazine hydrate in ethanol
6 h; Heating;
参考文献
Tang, Xiao-Qing; Hu, Chang-Ming
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 8 p. 1039 - 1044
反应条件
1.1: tetrahydrofuran / 1 h / Heating
1.2: tetrahydrofuran / 18 h / 20 °C
2.1: 63 percent / N2H4*H2O / ethanol / 12 h / Heating
View Scheme
参考文献
Teichert, Johannes; Oulie, Pascal; Jacob, Kane; Vendier, Laure; Etienne, Michel; Claramunt, Rosa M.; Lopez, Concepcion; Perez Medina, Carlos; Alkorta, Ibon; Elguero, Jose
New Journal of Chemistry, 2007 , vol. 31, # 6 p. 936 - 946
反应条件
palladium on activated charcoal in decalin
168 h; Heating;
参考文献
Teichert, Johannes; Oulie, Pascal; Jacob, Kane; Vendier, Laure; Etienne, Michel; Claramunt, Rosa M.; Lopez, Concepcion; Perez Medina, Carlos; Alkorta, Ibon; Elguero, Jose
New Journal of Chemistry, 2007 , vol. 31, # 6 p. 936 - 946
