2-甲基-4-硝基苯甲腈合成路线 （共 19 条）
反应条件
1: 98 percent / 80 percent aq. H2SO4 / 1.25 h / 100 °C 2: 88 percent / 6 N aq. HCl / 20 h / Heating 3: 99 percent / thionyl chloride / 21 h / 20 °C View Scheme
参考文献
Rosowsky, Andre; Forsch, Ronald A.; Null, Allison; Moran, Richard G.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 18 p. 3510 - 3519
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane 8 h; Heating / reflux;
参考文献
INOTEK PHARMACEUTICALS CORPORATION
Patent: WO2005/82368 A1, 2005 ;
Location in patent: Page/Page column 94-95 ;
反应条件
1: 98 percent / 80 percent aq. H2SO4 / 1.25 h / 100 °C 2: 88 percent / 6 N aq. HCl / 20 h / Heating 3: 99 percent / thionyl chloride / 21 h / 20 °C 4: N-bromosuccinimide; benzoyl peroxide / 1,2-dichloro-ethane / 48 h / Heating View Scheme
参考文献
Rosowsky, Andre; Forsch, Ronald A.; Null, Allison; Moran, Richard G.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 18 p. 3510 - 3519
反应条件
sodium hydroxide; dihydrogen peroxide in water Heating;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 6, # 3 p. 271 - 282
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. <2> 92, p. 149
参考文献
Chemische Berichte, , vol. 52, p. 1083
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile; bromine in tetrachloromethane
T=70°C; 5 h; IrradiationHeating / reflux;
参考文献
MERCKLE GMBH
Patent: WO2006/120010 A2, 2006 ;
Location in patent: Page/Page column 14; 44 ;
反应条件
in N,N-dimethyl-formamide
T=70°C; 2 h; Nitrogen atmosphere;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2007/76431 A1, 2007 ;
Location in patent: Page/Page column 65 ;
WO 2007/076431 A1
反应条件
1: 12 N aq. HCl; SnCl2*2H2O / dioxane / 4 h
2: 4.1 g / NIS; AcOH / 3 h
View Scheme
参考文献
Mackman; Katz; Breitenbucher; Hui; Verner; Luong; Liu; Sprengeler
Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3856 - 3871
