1: 40.8 percent / K2CO3 / dimethylsulfoxide / 30 h / Ambient temperature 2: ethyl acetate; diisopropyl ether 3: 94 percent / 15percent HCl/dioxane / Ambient temperature 4: DCC / tetrahydrofuran / Ambient temperature 5: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min 6: ethyl acetate; diisopropyl ether / 3 h / Ambient temperature 7: H2 / Pd / methanol / 2 h / 760 Torr / Ambient temperature View Scheme

1: 98.2 percent / H2 / Pd / methanol / 3 h / 760 Torr / Ambient temperature 2: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min 3: ethyl acetate; diisopropyl ether / 3 h / Ambient temperature 4: H2 / Pd / methanol / 2 h / 760 Torr / Ambient temperature View Scheme

1: 94 percent / 15percent HCl/dioxane / Ambient temperature 2: DCC / tetrahydrofuran / Ambient temperature 3: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min 4: ethyl acetate; diisopropyl ether / 3 h / Ambient temperature 5: H2 / Pd / methanol / 2 h / 760 Torr / Ambient temperature View Scheme

1: 79 percent / Et3N / dimethylsulfoxide / 18 h / 80 °C 2: 81 percent / H2 / 10percent Pd/C / methanol / 2 h / 735.5 Torr / Ambient temperature View Scheme

Tris-HCl buffer; human liver carboxylesterase pI 5.3 T=37°C; Hydrolysis; pH=7.4; Enzyme kinetics;

water; sodium chloride T=89.84°C; 6 h; Kinetics;