反应条件
1: 3,4-dihydro-2H-pyran; Merrifield resin-OC(O)CH2CH2CH(OH)CH2I With toluene-4-sulfonic acid
Solid phase reaction; addition;
2: piperidine in N,N-dimethyl-formamide
T=70°C; Solid phase reaction; substitution;
3: With trifluoroacetic acid in dichloromethane
Solid phase reaction; cleavage; cyclization; 4 h;
参考文献
Gouault; Cupif; Sauleau; David
Tetrahedron Letters, 2000 , vol. 41, # 38 p. 7293 - 7297
