N1-异丙基-4-氯-2-硝基苯胺合成路线 （共 6 条）
反应条件
in ethanol
T=150°C; 60 h; in a sealed tube;
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 6 p. 495 - 500
反应条件
borane-pyridine complex; trifluoroacetic acid
1.) toluene, 2.) toluene; Multistep reaction;
参考文献
Tapia, Ines; Alonso-Cires, Luisa; Lopez-Tudanca, Pedro Luis; Mosquera, Ramon; Labeaga, Luis; Innerarity, Ana; Orjales, Aurelio
Journal of Medicinal Chemistry, 1999 , vol. 42, # 15 p. 2870 - 2880
反应条件
sodium hydroxide; zinc in ethanol
1 h; Heating;
参考文献
Tapia, Ines; Alonso-Cires, Luisa; Lopez-Tudanca, Pedro Luis; Mosquera, Ramon; Labeaga, Luis; Innerarity, Ana; Orjales, Aurelio
Journal of Medicinal Chemistry, 1999 , vol. 42, # 15 p. 2870 - 2880
反应条件
hydrogenchloride in ethanol
参考文献
Kanebo Ltd.
Patent: US5407936 A1, 1995 ;
反应条件
1: 83 percent / zinc powder, 37percent HCl / aq. ethanol / 2 h / 35 - 40 °C
2: 42 percent / CHCl3 / 10 h / Heating
View Scheme
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 6 p. 495 - 500
反应条件
1: 99 percent / 1 N NaOH, zinc dust / ethanol / 1 h / Heating
2: tetrahydrofuran / Ambient temperature
View Scheme
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 6 p. 495 - 500
