5-氯-2-(异丙氨基)苯胺合成路线 （共 8 条）
反应条件
sodium hydroxide; zinc in ethanol
1 h; Heating;
参考文献
Tapia, Ines; Alonso-Cires, Luisa; Lopez-Tudanca, Pedro Luis; Mosquera, Ramon; Labeaga, Luis; Innerarity, Ana; Orjales, Aurelio
Journal of Medicinal Chemistry, 1999 , vol. 42, # 15 p. 2870 - 2880
反应条件
hydrogenchloride in ethanol
参考文献
Kanebo Ltd.
Patent: US5407936 A1, 1995 ;
反应条件
1: 1.) TFA, 2.) BH3*pyridine / 1.) toluene, 2.) toluene
2: 99 percent / 1 N NaOH, zinc dust / ethanol / 1 h / Heating
View Scheme
参考文献
Tapia, Ines; Alonso-Cires, Luisa; Lopez-Tudanca, Pedro Luis; Mosquera, Ramon; Labeaga, Luis; Innerarity, Ana; Orjales, Aurelio
Journal of Medicinal Chemistry, 1999 , vol. 42, # 15 p. 2870 - 2880
反应条件
1: 3.5 h / Heating
2: Zn (powder), 2.5 N NaOH / ethanol / 0.5 h / Heating
View Scheme
参考文献
Hori; Suzuki; Yamamoto; Nakajima; Ozaki; Ohtaka
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 10 p. 1832 - 1841
反应条件
in chloroform
10 h; Heating;
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 6 p. 495 - 500
反应条件
1: 42 percent / CHCl3 / 10 h / Heating
2: 78 percent / EtONa / ethanol / 5 h / Heating
View Scheme
参考文献
Kanebo Ltd.
Patent: US5407936 A1, 1995 ;
反应条件
in tetrahydrofuran
Ambient temperature;
参考文献
Tapia, Ines; Alonso-Cires, Luisa; Lopez-Tudanca, Pedro Luis; Mosquera, Ramon; Labeaga, Luis; Innerarity, Ana; Orjales, Aurelio
Journal of Medicinal Chemistry, 1999 , vol. 42, # 15 p. 2870 - 2880
反应条件
T=160°C; 4 h; Yield given;
参考文献
Hori; Suzuki; Yamamoto; Nakajima; Ozaki; Ohtaka
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 10 p. 1832 - 1841
