5,7-二氮杂螺[3.4]辛烷-6,8-二酮合成路线 （共 8 条）
反应条件
1: aq. NaOH / 72 h / Heating 2: 85 percent / HCl / 4 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 119, # 49 p. 11807 - 11816
参考文献
Ingold; Sako; Thorpe
Journal of the Chemical Society, 1922 , vol. 121, p. 1197
反应条件
1: aq. NaOH / 72 h / Heating 2: 65 percent / aq. NaOH / dioxane / 12 h / Ambient temperature View Scheme
参考文献
Palacin, Serge; Chin, Donovan N.; Simanek, Eric E.; MacDonald, John C.; Whitesides, George M.; McBride, Mary T.; Palmore, G. Tayhas R.
Journal of the American Chemical Society, 1997 , vol. 119, # 49 p. 11807 - 11816
反应条件
sodium hydroxide 50 h; Heating;
参考文献
Pirrung; Cao; Chen
Journal of Organic Chemistry, 1995 , vol. 60, # 18 p. 5790 - 5794
反应条件
1: in ethanol; water
T=70°C; 6 h; Inert atmosphere;
2: With hydrogenchloride in ethanol; water
T=23°C; 10 h;
参考文献
Ipsen Pharma S.A.S.
Patent: US2012/83514 A1, 2012 ;
Location in patent: Page/Page column 19 ;
反应条件
anhydrous ammonium carbonate in ethanol
T=60°C; 2 h;
参考文献
Palacin, Serge; Chin, Donovan N.; Simanek, Eric E.; MacDonald, John C.; Whitesides, George M.; McBride, Mary T.; Palmore, G. Tayhas R.
Journal of the American Chemical Society, 1997 , vol. 119, # 49 p. 11807 - 11816
反应条件
in ethanol; water
6 h; Heating;
参考文献
Tsang, Joseph W.; Schmied, Bernhard; Nyfeler, Rolf; Goodman, Murray
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1663 - 1668
参考文献
Ingold; Sako; Thorpe
Journal of the Chemical Society, 1922 , vol. 121, p. 1197
