反应条件
1: ammonium acetate; acetic acid / 4.5 h / 110 °C / Inert atmosphere 2: sodium tetrahydroborate / tetrahydrofuran; methanol / 0 - 20 °C / Inert atmosphere 3: palladium 10 on activated carbon; hydrogen / ethanol / 20 °C / Inert atmosphere 4: triethylamine / dichloromethane / 0 °C / Inert atmosphere View Scheme
参考文献
Hoveyda, Hamid R.; Marsault, Eric; Gagnon, Rene; Mathieu, Axel P.; Vezina, Martin; Landry, Annick; Wang, Zhigang; Benakli, Kamel; Beaubien, Sylvie; Saint-Louis, Carl; Brassard, Martin; Pinault, Jean-Francois; Ouellet, Luc; Bhat, Shridhar; Ramaseshan, Mahesh; Peng, Xiaowen; Foucher, Laurence; Beauchemin, Sophie; Bherer, Patrick; Veber, Daniel F.; Peterson, Mark L.; Fraser, Graeme L.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 24 p. 8305 - 8320