反应条件
1: N-(2-hydroxy-ethyl)-piperazine With potassium carbonate; potassium iodide in N,N-dimethyl-formamide T=20°C; 2: 1-chloro-1,1-diphenylmethane in N,N-dimethyl-formamide T=20 - 70°C;
参考文献
Burgess, Steven J.; Kelly, Jane X.; Shomloo, Shawheen; Wittlin, Sergio; Brun, Reto; Liebmann, Katherine; Peyton, David H.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 17 p. 6477 - 6489