1-(5-氯-2,4-二羟基苯基)乙酮合成路线 （共 5 条）
反应条件
1: With boron trifluoride diethyl etherate
T=80°C;
2: With water; sodium acetate
T=20°C; 2.5 h;
参考文献
Qian, Changgeng; Cai, Xiong; Zhai, Haixiao
Patent: US2009/76006 A1, 2009 ;
Location in patent: Page/Page column 28; 35 ;
US 20090076006 A1
反应条件
thionyl chloride in dichloromethane
T=20°C; 48 h; Inert atmosphere;
参考文献
Jeong, Chul-Ho; Park, Hee Baek; Jang, Won Jun; Jung, Su Hyun; Seo, Young Ho
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 1 p. 224 - 227
反应条件
potassium carbonate in acetonitrile
T=20°C; Reflux;
参考文献
SIGMA-TAU RESEARCH SWITZERLAND S.A.; GIANNINI, Giuseppe; CABRI, Walter; SIMONI, Daniele; BARUCCHELLO, Ricardo; CARMINATI, Paolo; PISANO, Claudio
Patent: WO2010/748 A1, 2010 ;
Location in patent: Page/Page column 25; 26 ;
WO 2010/000748 A1
反应条件
potassium carbonate in acetonitrile
48 h; Heating / reflux;
参考文献
Qian, Changgeng; Cai, Xiong; Zhai, Haixiao
Patent: US2009/76006 A1, 2009 ;
Location in patent: Page/Page column 28; 35 ;
US 20090076006 A1
反应条件
1: 90 percent / K2CO3 / acetonitrile / 6 h / Heating
2: 84 percent / 5 h / 150 °C
3: 92 percent / hydrazine hydrate / ethanol / 5.25 h / Heating
View Scheme
参考文献
Brough, Paul A.; Barril, Xavier; Beswick, Mandy; Dymock, Brian W.; Drysdale, Martin J.; Wright, Lisa; Grant, Kate; Massey, Andrew; Surgenor, Allan; Workman, Paul
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 23 p. 5197 - 5201
