7-溴-5-甲氧基苯并呋喃合成路线 （共 4 条）
反应条件
polyphosphoric acid in toluene
T=70°C; 1 h; Inert atmosphere;
参考文献
BEIGENE, LTD.; ZHOU, Changyou; WANG, Shaohui; ZHANG, Guoliang
Patent: WO2013/97224 A1, 2013 ;
Location in patent: Page/Page column 73 ;
参考文献
ELI LILLY AND COMPANY
Patent: EP1204654 B1, 2003 ;
EP 1204654 B1
反应条件
1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 120 °C / |Inert atmosphere
2: polyphosphoric acid / toluene / 1 h / 70 °C / |Inert atmosphere
View Scheme
参考文献
BEIGENE, LTD.; ZHOU, Changyou; WANG, Shaohui; ZHANG, Guoliang
Patent: WO2013/97224 A1, 2013 ;
反应条件
1: bromine / chloroform / 2 h / 0 - 20 °C
2: caesium carbonate / N,N-dimethyl-formamide / 2 h / 120 °C / |Inert atmosphere
3: polyphosphoric acid / toluene / 1 h / 70 °C / |Inert atmosphere
View Scheme
参考文献
BEIGENE, LTD.; ZHOU, Changyou; WANG, Shaohui; ZHANG, Guoliang
Patent: WO2013/97224 A1, 2013 ;
