(S)-1-苄基-5-氧代吡咯烷-2-羧酸叔丁酯合成路线 （共 6 条）
反应条件
1: tert-Butyl (S)-5-oxo-2-pyrrolidinecarboxylate With sodium hydride in tetrahydrofuran
T=20°C; 0.0833333 h;
2: benzyl bromide in tetrahydrofuran
T=20°C; 0.5 h;
参考文献
Itoh, Takashi; Matsuya, Yuji; Enomoto, Yasuko; Ohsawa, Akio
Tetrahedron, 2001 , vol. 57, # 34 p. 7277 - 7289
反应条件
sodium hydride in tetrahydrofuran
1 h; Heating;
参考文献
Itoh, Takashi; Miyazaki, Michiko; Ikeda, Sachiko; Nagata, Kazuhiro; Yokoya, Masashi; Matsuya, Yuji; Enomoto, Yasuko; Ohsawa, Akio
Tetrahedron, 2003 , vol. 59, # 19 p. 3527 - 3536
反应条件
pyridine in N,N-dimethyl-formamide; acetonitrile
15 h; Ambient temperature; Yield given;
参考文献
Peterson,J.S.; Fels,G.; Rapoport,H.
Journal of the American Chemical Society, 1984 , vol. 106, p. 4539
反应条件
1-methyl-piperidine; hydrogen; triphenylphosphine; platinum on activated charcoal
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Hernandez, Andres S.; Thaler, Adrian; Castells, Josep; Rapoport, Henry
Journal of Organic Chemistry, 1996 , vol. 61, # 1 p. 314 - 323
反应条件
1: 100 percent / HClO4 / H2O / 18 h / 20 °C
2: 48 percent / NaH / CH2Cl2 / 14 h
View Scheme
参考文献
Hussaini, Syed Raziullah; Moloney, Mark G.
Synthetic Communications, 2005 , vol. 35, # 8 p. 1129 - 1134
反应条件
trifluoroacetic acid in dichloromethane
T=20°C; 7 h;
参考文献
Itoh, Takashi; Miyazaki, Michiko; Ikeda, Sachiko; Nagata, Kazuhiro; Yokoya, Masashi; Matsuya, Yuji; Enomoto, Yasuko; Ohsawa, Akio
Tetrahedron, 2003 , vol. 59, # 19 p. 3527 - 3536
