4-溴-5-甲氧基-1H-吲哚合成路线 （共 4 条）
反应条件
1: in N,N-dimethyl-formamide
T=90°C;
2: With iron; acetic acid in N,N-dimethyl-formamide
1 h; Heating / reflux;
参考文献
BIOVITRUM AB (publ)
Patent: WO2008/3703 A1, 2008 ;
Location in patent: Page/Page column 119-120 ;
WO 2008/003703 A1
反应条件
in tetrahydrofuran
T=-40 - -20°C; 0.5 h;
参考文献
Roche Palo Alto LLC
Patent: US2007/123527 A1, 2007 ;
Location in patent: Page/Page column 66-67 ;
反应条件
Rh(dppp)2Cl
18 h; Heating;
参考文献
Meyer; Kruse
Journal of Organic Chemistry, 1984 , vol. 49, # 17 p. 3195 - 3199
反应条件
1: 1.) LiAlH4 / tetrahydrofuran / 0 °C / 1.) 15 min, 2.) 45 min
2: MnO2 / CH2Cl2 / 1 h / 25 °C
3: 95 percent / Rh(dppp)2Cl / 18 h / Heating
View Scheme
参考文献
Meyer; Kruse
Journal of Organic Chemistry, 1984 , vol. 49, # 17 p. 3195 - 3199
