(3-苯基-5-异恶唑基)甲醇合成路线 （共 22 条）
反应条件
silver(l) oxide in ethanol Heating;
参考文献
Gazzetta Chimica Italiana, , vol. 90, p. 1239 - 1252
反应条件
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -40 °C / Inert atmosphere 2.2: -40 - 20 °C / Inert atmosphere 3.1: silver tetrafluoroborate; phenol / tetrahydrofuran / 1 h / Reflux View Scheme
参考文献
Tetrahedron, , vol. 67, # 25 p. 4612 - 4615
反应条件
1.1: pyridine; sodium sulfate / methanol / 4 h / 20 °C / Inert atmosphere 2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere 3.1: n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -40 °C / Inert atmosphere 3.2: -40 - 20 °C / Inert atmosphere 4.1: silver tetrafluoroborate; phenol / tetrahydrofuran / 1 h / Reflux View Scheme
参考文献
Tetrahedron, , vol. 67, # 25 p. 4612 - 4615
参考文献
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, , vol. <8> 14, p. 95,97, 275, 278
反应条件
pyridine hydrogenfluoride; triethylamine 1.) THF, 25 deg C, 3 h, 2.) CH2Cl2, 25 deg C, 4 h, 3.) Et2O, 25 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Tetrahedron, , vol. 53, # 19 p. 6681 - 6696
反应条件
1: ethanolic sodium ethylate / 140 - 160 °C / Erhitzen des Reaktionsprodukts mit wss. HCl 2: aqueous NaOH View Scheme
参考文献
Gazzetta Chimica Italiana, , vol. 73, p. 99,103
参考文献
Gazzetta Chimica Italiana, , vol. 73, p. 99,103
参考文献
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, , vol. <8>14, p. 95,275,276,278
反应条件
1: With methanesulfonyl chloride; triethylamine in dichloromethane T=20°C; 6 h; Cooling; 2: With sodium azide in N,N-dimethyl-formamide T=55°C; 8 h; 3: With ammonium chloride; zinc in ethanol; water 0.5 h; Reflux;
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 50, # 5 p. 695 - 703
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane T=-78°C; 0.5 h; 2: With triethylamine in dichloromethane T=-78 - 20°C;
参考文献
Du, Chao; Li, Liqi; Li, Ying; Xie, Zhixiang
Angewandte Chemie - International Edition, 2009 , vol. 48, # 42 p. 7853 - 7856
