(1-重氮-2-氧代-丙醇)-膦酸二甲酯合成路线 （共 103 条）
反应条件
1: With sodium hydride in tetrahydrofuran; mineral oil; benzene T=20°C; 1 h; Inert atmosphereCooling with ice; 2: With 4-toluenesulfonyl azide in tetrahydrofuran; mineral oil; benzene T=20°C; Inert atmosphere;
参考文献
Wijtmans, Maikel; De Graaf, Chris; De Kloe, Gerdien; Istyastono, Enade P.; Smit, Judith; Lim, Herman; Boonnak, Ratchanok; Nijmeijer, Saskia; Smits, Rogier A.; Jongejan, Aldo; Zuiderveld, Obbe; De Esch, Iwan J. P.; Leurs, Rob
Journal of Medicinal Chemistry, 2011 , vol. 54, # 6 p. 1693 - 1703
反应条件
1: (2-oxo-propyl)-phosphonic acid dimethyl ester With sodium hydride in tetrahydrofuran T=0°C; 1 h; 2: 4-toluenesulfonyl azide in tetrahydrofuran T=0°C; 0.166667 h;
参考文献
SCHERING CORPORATION
Patent: WO2007/97937 A1, 2007 ;
Location in patent: Page/Page column 190 ;
WO 2007/097937 A1
反应条件
potassium carbonate in tetrahydrofuran T=0°C; 48 h;
参考文献
Helvetica Chimica Acta, , vol. 88, # 11 p. 2918 - 2937
反应条件
potassium carbonate in methanol T=20°C;
参考文献
Paterson, Ian; Menche, Dirk; Hakansson, Anders E.; Longstaff, Adrian; Wong, David; Barasoain, Isabel; Buey, Ruben M.; Diaz, J. Fernando
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 9 p. 2243 - 2247
反应条件
potassium carbonate in methanol 4 h;
参考文献
Koufaki, Maria; Theodorou, Elissavet; Galaris, Dimitrios; Nousis, Lambros; Katsanou, Efrosini S.; Alexis, Michael N.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 300 - 306
反应条件
potassium carbonate in tetrahydrofuran; methanol T=20°C;
参考文献
Synlett, , # 19 p. 3037 - 3041
反应条件
potassium carbonate in tetrahydrofuran; methanol T=20°C;
参考文献
Maisonneuve, Stephane; Xie, Juan
Synlett, 2009 , # 18 p. 2977 - 2981
反应条件
potassium carbonate in methanol T=25°C; 1 h; Inert atmosphere;
参考文献
Chemistry - A European Journal, , vol. 19, # 46 p. 15682 - 15688
反应条件
1: (4-nitro-phenyl)-methanol With manganese(IV) oxide in tetrahydrofuran T=20°C; 4 h; 2: (1-Diazo-2-oxo-propyl)-phosphonic acid dimethyl ester With potassium carbonate in tetrahydrofuran; methanol T=20°C;
参考文献
Tetrahedron, , vol. 62, # 28 p. 6673 - 6680
反应条件
potassium carbonate in methanol 18 h; Inert atmosphere;
参考文献
Synlett, , # 19 art. no. S07111ST, p. 2799 - 2802
