(1-重氮-2-氧代-丙醇)-膦酸二甲酯合成路线 （共 103 条）
反应条件
methanol; potassium carbonate in dichloromethane T=0 - 20°C; Seyferth-Gilbert Homologation;
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 34 p. 8957 - 8960
Angew. Chem., , vol. 125, # 34 p. 9126 - 9129,4
反应条件
methanol; potassium carbonate
T=20°C; 3 h;
参考文献
UCB PHARMA S.A.
Patent: WO2007/141504 A1, 2007 ;
Location in patent: Page/Page column 55-56 ;
WO 2007/141504 A1
反应条件
potassium carbonate in methanol
参考文献
MERCK and CO., INC.
Patent: WO2008/156580 A1, 2008 ;
Location in patent: Page/Page column 30 ;
WO 2008/156580 A1
反应条件
potassium carbonate in tetrahydrofuran; methanol
T=20°C; 16 h;
参考文献
Lin, Fang; Peng, Hai-Yan; Chen, Jing-Xing; Chik, David T.W.; Cai, Zongwei; Wong, Keith M.C.; Yam, Vivian W. W.; Wong, Henry N. C.
Journal of the American Chemical Society, 2010 , vol. 132, # 46 p. 16383 - 16392
反应条件
potassium carbonate
T=0 - 23°C; 14 h; Inert atmosphere;
参考文献
Wzorek, Joseph S.; Knoepfel, Thomas F.; Sapountzis, Ioannis; Evans, David A.
Organic Letters, 2012 , vol. 14, # 23 p. 5840 - 5843
反应条件
1: (4S)-2,2-Dimethyl-4-(N-methoxy-N-methylcarbamoyl)oxazolidin-3-carbonsaeure-(tert-butyl)ester With lithium aluminium tetrahydride in tetrahydrofuran
T=20°C; 0.5 h; Inert atmosphere;
2: (1-Diazo-2-oxo-propyl)-phosphonic acid dimethyl ester in methanol
T=0°C; 0.5 h; Inert atmosphere;
3: With potassium carbonate in methanol
T=20°C; 15 h; Inert atmosphere;
参考文献
Temperini, Andrea; Capperucci, Antonella; Degl'Innocenti, Alessandro; Terlizzi, Raffaella; Tiecco, Marcello
Tetrahedron Letters, 2010 , vol. 51, # 31 p. 4121 - 4124
反应条件
1: (L)-3-tert.butoxycarbonyl-2,2-dimethyl-oxazolidine-4-carboxylic acid-N-methoxy-N-methyl-amide With lithium aluminium tetrahydride in tetrahydrofuran
T=20°C; 0.5 h; Inert atmosphere;
2: (1-Diazo-2-oxo-propyl)-phosphonic acid dimethyl ester in methanol
T=0°C; 0.5 h; Inert atmosphere;
3: With potassium carbonate in methanol
T=20°C; 15 h; Inert atmosphere;
参考文献
Temperini, Andrea; Capperucci, Antonella; Degl'Innocenti, Alessandro; Terlizzi, Raffaella; Tiecco, Marcello
Tetrahedron Letters, 2010 , vol. 51, # 31 p. 4121 - 4124
反应条件
potassium tert-butylate in methanol
T=100°C; 0.5 h;
参考文献
Baxendale, Ian R.; Ley, Steven V.; Mansfield, Andrew C.; Smith, Christopher D.
Angewandte Chemie, International Edition, 2009 , vol. 48, p. 4017 - 4021
Angewandte Chemie, 2009 , vol. 121, p. 4077 - 4081
反应条件
potassium carbonate in methanol
T=20°C;
参考文献
The University of Tokyo; Riken; NAGANO Tetsuo; OKABE Takayoshi; KOJIMA Hirotatsu; SAITO Nae; NAKANO Hirofumi; ABE Masanao; TANAKA Akiko; HONMA Teruki; YOKOYAMA Shigeyuki; TSUGANEZAWA Keiko; YUKI Hitomi
Patent: EP2565192 A1, 2013 ;
Location in patent: Paragraph 0546 ;
反应条件
hydrogenchloride in ethanol
T=20°C;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2004/80998 A1, 2004 ;
Location in patent: Page 27; 21 ;
WO 2004/080998 A1
