1,2-二(溴甲基)苯合成路线 （共 196 条）
反应条件
1: 30.1 percent / 3 h / 215 - 220 °C
2: 46 percent / 95percent HNO3 / acetic acid / 7 h / Heating
View Scheme
参考文献
Lisitsyn, V. N.; Borovkov, A. G.
Journal of Organic Chemistry USSR (English Translation), 1983 , p. 2270 - 2272
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 12 p. 2588 - 2590
反应条件
sodium hydride
1.) tetrahydrofuran, 20 min, 2.) tetrahydrofuran, RT, 6 h; Yield given. Multistep reaction;
参考文献
Bigge, Christopher F.; Johnson, Graham; Ortwine, Daniel F.; Drummond, James T.; Retz, Daniel M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 8 p. 1371 - 1384
反应条件
1: 54 percent / Zn / acetonitrile / 4 h / 50 °C
2: 97 percent / KF / ethanol / Ambient temperature
3: 2,4,6-tri-t-butylphenol, NBS / dioxane / 16 h / 50 °C
View Scheme
参考文献
Tamao, Kohei; Yoshida, Jun-ichi; Akita, Munetaka; Sugihara, Yoshihiro; Iwahara, Takahisa; Kumada, Makoto
Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 1 p. 255 - 260
反应条件
N-ethyl-N,N-diisopropylamine
参考文献
Iddon, Brian; Redhouse, Alan D.; Yat, Patrick N.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 4 p. 1083 - 1090
反应条件
1: potassium carbonate / acetonitrile
2: Pd[P(t-Bu3)]2; cyclohexene / 1,4-dioxane / 14 h / 110 °C
View Scheme
参考文献
Chrostowska, Anna; Maziere, Audrey; Dargelos, Alain; Graciaa, Alain; Darrigan, Clovis; Weber, Lothar; Halama, Johannes
European Journal of Inorganic Chemistry, 2013 , # 33 p. 5672 - 5678
反应条件
argentic oxide
0.5 h; Ambient temperatureIrradiation;
参考文献
Ortiz; Walls; Yuste; Barrios; Sanchez-Obregon; Pinelo
Synthetic Communications, 1993 , vol. 23, # 6 p. 749 - 756
参考文献
Wang, Wuyi; Li, Tiechao; Attardo, Giorgio
Journal of Organic Chemistry, 1997 , vol. 62, # 19 p. 6598 - 6602
反应条件
1: 80 percent / potassium carbonate / acetonitrile / 14 h / Heating
2: 94 percent / lithium aluminum hydride / diethyl ether; tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Hou, Duen-Ren; Hsieh, Yih-Dar; Hsieh, Yi-Wei
Tetrahedron Letters, 2005 , vol. 46, # 35 p. 5927 - 5929
反应条件
potassium carbonate in dimethyl sulfoxide
T=20°C; 72 h;
参考文献
Bose, Gopal; Ullah, Ehsan; Langer, Peter
Chemistry - A European Journal, 2004 , vol. 10, # 23 p. 6015 - 6028
反应条件
sodium hydride in dimethyl sulfoxide
T=50°C; 2 h;
参考文献
Ridvan, Ludek; Zavada, Jiri
Tetrahedron, 1997 , vol. 53, # 43 p. 14793 - 14806
