反应条件
1.1: AlCl3, aluminium chloride / dichloromethane / 0.42 h / -10 - 2 °C / |Inert atmosphere 1.2: 0.42 h / -4 - 1 °C / |Inert atmosphere 2.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 - 7 °C / |Inert atmosphere 2.2: 0.28 h / 18 °C 2.3: 0.67 h / -70 - -55 °C 3.1: hydrogenchloride / methanol / 6.5 h / 44 - 54 °C / |Inert atmosphere; |Large scale 4.1: palladium 10 on activated carbon; hydrogen / 1-Propyl acetate / 8 h / 100 °C / 51716.2 Torr View Scheme
参考文献
Li, Xu; Jiang, Jian-Hong; Chen, Qingqi; Xiao, Sheng-Xiong; Li, Chuan-Hua; Gu, Hui-Wen; Zhang, Hui; Hu, Ji-Lin; Yao, Fei-Hong; Li, Qiang-Guo
European Journal of Medicinal Chemistry, 2013 , vol. 62, p. 605 - 613