1,2,3,4-四氢异喹啉合成路线 （共 340 条）
反应条件
[Ni(1,2-bis(di-isopropylphosphino)ethane)(μ-H)]2 in 1,4-dioxane T=180°C; 72 h; Inert atmosphere;
参考文献
Organometallics, , vol. 30, # 12 p. 3340 - 3345
参考文献
Potter; Taylor
Journal of the Chemical Society, 1953 , p. 1320
反应条件
1: 70 percent / Et3N / toluene / 2 h / 100 °C 2: 40 percent / LiAlH4 / tetrahydrofuran / 1 h / 0 °C View Scheme
参考文献
Mach, Robert H.; Huang, Yunsheng; Freeman, Rebekah A.; Wu, Li; Vangveravong, Suwanna; Luedtke, Robert R.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 1 p. 195 - 202
反应条件
in toluene 9 h; Heating;
参考文献
Anderson; Belelli; Bennett; Buchanan; Casula; Cooke; Feilden; Gemmell; Hamilton; Hutchinson; Lambert; Maidment; McGuire; McPhail; Miller; Muntoni; Peters; Sansbury; Stevenson; Sundaramt
Journal of Medicinal Chemistry, 2001 , vol. 44, # 22 p. 3582 - 3591
参考文献
Okimoto, Mitsuhiro; Yoshida, Takashi; Hoshi, Masayuki; Hattori, Kazuyuki; Komata, Masashi; Numata, Kaori; Tomozawa, Kenta
Australian Journal of Chemistry, 2007 , vol. 60, # 4 p. 236 - 242
反应条件
triethylamine in dichloromethane 1 h; Yield givenYields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 64, # 2 p. 611 - 617
反应条件
1.1: N-bromosuccinmide / dichloromethane / 0.5 h / 20 °C / Inert atmosphere 1.2: 1 h / 20 °C / Inert atmosphere 2.1: sulfuric acid; potassium nitrate / 6 h / 0 - 60 °C / Inert atmosphere 3.1: manganese(IV) oxide / toluene / 2 h / Inert atmosphere; Reflux 4.1: palladium 10 on activated carbon; hydrogen / methanol / 3 h / 760.05 Torr 5.1: hydrogen bromide; copper(I) bromide; sodium nitrite / water / 12.5 h / 0 - 75 °C / Inert atmosphere View Scheme
参考文献
Shi, Jun; Manolikakes, Georg; Yeh, Chien-Hung; Guerrero, Carlos A.; Shenvi, Ryan A.; Shigehisa, Hiroki; Baran, Phil S.
Journal of the American Chemical Society, 2011 , vol. 133, # 20 p. 8014 - 8027
反应条件
P2O5/silica gel; nitric acid in water T=20°C; 0.333333 h;
参考文献
Hajipour, Abdol R.; Guo, Lian-Wang; Pal, Arindam; Mavlyutov, Timur; Ruoho, Arnold E.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 24 p. 7435 - 7440
反应条件
1: With sulfuric acid; potassium nitrate T=0 - 20°C; 3 h; 2: With ammonia in water T=0°C; pH=10;
参考文献
CELLZOME AG
Patent: WO2009/62658 A1, 2009 ;
Location in patent: Page/Page column 36 ;
WO 2009/062658 A1
反应条件
1: With 1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile P=760.051 Torr; 0.75 h; 2: With tributylphosphine; di-tert-butylazodicarboxylate in acetonitrile Mitsunobu reaction; P=760.051 Torr; Inert atmosphere;
参考文献
Peterson, Scott L.; Stucka, Sabrina M.; Dinsmore, Christopher J.
Organic Letters, 2010 , vol. 12, # 6 p. 1340 - 1343
