1,2,3,4-四氢异喹啉合成路线 （共 340 条）
参考文献
McNeilab, Inc.
Patent: US4656291 A1, 1987 ;
反应条件
1: copper(l) iodide; potassium phosphate / ethylene glycol; isopropyl alcohol / 24 h / 20 - 90 °C / Inert atmosphere 2: 2,4,5,7-tetrabromofluorescein / N,N-dimethyl-formamide / 10 h / 20 °C / Irradiation View Scheme
参考文献
Alagiri, Kaliyamoorthy; Prabhu, Kandikere Ramaiah
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 4 p. 835 - 842
参考文献
v. Braun; Goll
Chemische Berichte, 1927 , vol. 60, p. 341
反应条件
[Ni(1,2-bis(di-isopropylphosphino)ethane)(μ-H)]2 in 1,4-dioxane T=180°C; 72 h; Inert atmosphere;
参考文献
Organometallics, , vol. 30, # 12 p. 3340 - 3345
反应条件
benzophenone in benzene 24 h; Irradiation;
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 30, # 5 p. 525 - 526
反应条件
pyridine in dichloromethane
T=20°C; 2 h;
参考文献
Lemoucheux, Laurent; Rouden, Jacques; Ibazizene, Meziane; Sobrio, Franck; Lasne, Marie-Claire
Journal of Organic Chemistry, 2003 , vol. 68, # 19 p. 7289 - 7297
反应条件
triethylamine in tetrahydrofuran; toluene
T=-78°C; 1 h;
参考文献
Bristol-Myers Squibb Co.
Patent: US6335324 B1, 2002 ;
Location in patent: Page column 102 ;
US 6335324 B1
反应条件
1: NaOH / toluene; H2O / 12 h / 20 °C
2: 2.48 g / LiAlH4 / tetrahydrofuran / 36 h / Heating
3: 3 percent Spectr. / diethyl ether / 1 h / 20 °C
View Scheme
参考文献
Lemoucheux, Laurent; Rouden, Jacques; Ibazizene, Meziane; Sobrio, Franck; Lasne, Marie-Claire
Journal of Organic Chemistry, 2003 , vol. 68, # 19 p. 7289 - 7297
参考文献
Lemoucheux, L.; Rouden, J.; Ibazizene, M.; Sobrio, F.; Lasne, M.-C.
Journal of Labelled Compounds and Radiopharmaceuticals, 2001 , vol. 44, p. S128 - S131
反应条件
in dichloromethane
T=20°C; 3 h;
参考文献
Lemoucheux, Laurent; Rouden, Jacques; Ibazizene, Meziane; Sobrio, Franck; Lasne, Marie-Claire
Journal of Organic Chemistry, 2003 , vol. 68, # 19 p. 7289 - 7297
