1,2,3,4-四氢异喹啉合成路线 （共 340 条）
反应条件
sodium tetrahydroborate; 2-chloropyridine hydrochloride in tetrahydrofuran
T=70°C; Alkylation; Reductive amination; 15 h;
参考文献
Perrio-Huard, Cecile; Aubert, Catherine; Lasne, Marie-Claire
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 3 p. 311 - 316
反应条件
Yield given. Multistep reaction;
参考文献
Morphy, J. Richard; Rankovic, Zoran; Rees, David C.
Tetrahedron Letters, 1996 , vol. 37, # 18 p. 3209 - 3212
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 140 °C
2.1: sodium tetrahydroborate; iodine / tetrahydrofuran / 4 h / 0 °C / |Inert atmosphere; |Reflux
2.2: 0.5 h / |Reflux
View Scheme
参考文献
Sun, Xiang; Hu, Yu; Nie, Shao-Zhen; Yan, Yun-Yun; Zhang, Xue-Jing; Yan, Ming
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 11-12 p. 2179 - 2184
反应条件
[3IPtBuPd(allyl)]OTf in benzene-d6
T=25°C; 20 h; GloveboxInert atmosphereSealed tube;
参考文献
Beck, John F.; Samblanet, Danielle C.; Schmidt, Joseph A. R.
RSC Advances, 2013 , vol. 3, # 43 p. 20708 - 20718
反应条件
1: dinitrogen tetraoxide; acetic acid
2: aq. NaOH solution
View Scheme
参考文献
Wegler; Frank
Chemische Berichte, 1937 , vol. 70, p. 1279,1285
参考文献
Wegler; Frank
Chemische Berichte, 1937 , vol. 70, p. 1279,1285
反应条件
1: 1) aq.KClO 2) benzyltriethylammonium chloride / 1) CH2Cl2, 48 deg C, 2) overnight
2: 90 percent / CH2Cl2 / 0 °C
3: 30percent aq.Na2CO3, H2O2 / CH2Cl2
View Scheme
参考文献
Hanquet; Lusinchi; Milliet
Tetrahedron, 1993 , vol. 49, # 2 p. 423 - 438
反应条件
sulfuric acid; sodium nitrite
Erwaermen des Reaktionsprodukts mit Lithiumalanat in Aether;
参考文献
De Jong, Johannes C.; Sorensen, Lotte G.; Tornqvist, Hans; Jacobsen, Poul
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 7 p. 1741 - 1744
反应条件
1: 1.) N-bromosuccinimide, 2.) aq. NaOH / 1.) CH2Cl2, 30 min, 2.) CH2Cl2, 25 deg C, 1 h
2: 88 percent / 1 h / Heating
3: 79 percent / polyphosphoric acid / 1.25 h / Heating
View Scheme
参考文献
Pelletier, Jeffrey C.; Cava, Michael P.
Journal of Organic Chemistry, 1987 , vol. 52, # 4 p. 616 - 622
参考文献
Ali; Gleason; Hill; Krell; Kruse; Lavanchy; Volpe
Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1235 - 1240
