4,5,6,7-四氢-1-苯并噻吩-2-羧酸甲酯合成路线 （共 2 条）
反应条件
1: With triethylamine in pyridine
T=20°C; 2 h;
2: With sodium methylate in methanol
3 h; Reflux;
参考文献
GLAXOSMITHKLINE LLC; HAYDAR, Simon N.; JOHNS, Brian Alvin; VELTHUISEN, Emile Johann
Patent: WO2013/43553 A1, 2013 ;
Location in patent: Page/Page column 115-116 ;
反应条件
1.1: trichlorophosphate / 0.5 h / 0 - 20 °C
1.2: 12 h / 0 - 20 °C
2.1: triethylamine / pyridine / 2 h / 20 °C
2.2: 3 h / |Reflux
View Scheme
参考文献
GLAXOSMITHKLINE LLC; HAYDAR, Simon N.; JOHNS, Brian Alvin; VELTHUISEN, Emile Johann
Patent: WO2013/43553 A1, 2013 ;
